A case of breast cancer with endocrine features
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Cancer with endocrine features rarely occurs in the breast. We report a case of breast cancer with endocrine features in an 80-year-old woman. The tumors were treated by wide excision and a postoperative histopathologic diagnosis of carcinoma of the breast with endocrine features was made. Immunostaining was positive for chromogranin A, neuron-specific enolase and synaptophysin, but weakly argyrophilic. Widespread metastases occurred two months postoperatively, and the patient died of breast cancer 6 months after the first treatment.
Key wordsBreast cancer Endocrine features Chromogranin
Carbohydrate antigen 15-3
Follicle stimulating hormone
Anti-epitherial keratin 1/3
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- 4).O’Conner DF, Deftos LJ: Secretion of chromogranin A by peptide-producing endocrine neoplasms.N Engl J Med 314:1145–1151, 1986.Google Scholar
- 13).Buffa R, Rindi G, Sessa F,et al: Synaptophysin immunoreactivity and small clear vesicle in neuro-endocrine cells and related tumours.Mol Cell Probes 2:367–381, 1988Google Scholar
- 15).Laforga JB, Lopez LI: Breast carcinoma with endocrine features; Report of a case with cytologic and immunohistochemical studies. Acta Cytol :1017–1021, 1998.Google Scholar
- 17).Graziano SL, Mazid R, Newman N,et al: The use of neuroendocrine immunoperoxidase markers to predict chemotherapy response in patients with non-small-cell lung cancer.J Clin Oncol 7:1398–1406, 1987.Google Scholar