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Breast Cancer

, Volume 5, Issue 1, pp 77–81 | Cite as

Acinic cell adenocarcinoma arising in the breast of a young male: A clinicopathological, immunohistochemical and ultrastructural study

  • Kazuya Shimao
  • Shunsuke Haga
  • Tadao Shimizu
  • Hiroshi Imamura
  • Osamu Watanabe
  • Jun Kinoshita
  • Hirosni Nagumo
  • Yoshihito Utada
  • Toshiro Okabe
  • Tetsuro Kajiwara
  • Nobuyuki Oshibe
  • Motohiko Aiba
Case Report

Abstract

A 23-year-old man with acinic cell adenocarcinoma of the breast is reported. He presented with a 4.8 × 4.2 cm mass in his left breast, and excisional biopsy was performed. Under the light microscope, tumor cells had abundant periodic acid-Schiff-positive secretory granules and eosinophilic cytoplasms. Electron microscopy revealed the granules to have various electron densities, a finding characteristic of acinic cell adenocarcinoma. Immunohistochemically, the tumor cells were stained with salivary-type amylase. Electron microscopic and immunohistochemical investigation greatly facilitated the diagnosis of this acinic cell adenocarcinoma, which was in an unusual location. We believe this is the first case report of acinic cell adenocarcinoma of the mammary gland studied utilizing light microscopic, ultrastructural and immunohistochemical techniques.

Key words

Acinic cell adenocarcinoma Breast Immunohistochemistry Ultrastructure Salivary-type amylase 

Abbreviations

GCDFP-15

Gross cystic disease fluid protein 15

EMA

Epithelial membrane antigen

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Copyright information

© The Japanese Breast Cancer Society 1998

Authors and Affiliations

  • Kazuya Shimao
    • 1
  • Shunsuke Haga
    • 1
  • Tadao Shimizu
    • 1
  • Hiroshi Imamura
    • 1
  • Osamu Watanabe
    • 1
  • Jun Kinoshita
    • 1
  • Hirosni Nagumo
    • 1
  • Yoshihito Utada
    • 1
  • Toshiro Okabe
    • 1
  • Tetsuro Kajiwara
    • 1
  • Nobuyuki Oshibe
    • 1
    • 2
  • Motohiko Aiba
    • 2
  1. 1.Department of SurgeryTokyo Women’s Medical College Daini HospitalTokyoJapan
  2. 2.Department of Surgical PathologyTokyo Women’s Medical College Daini HospitalJapan

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