Breast Cancer

, Volume 7, Issue 1, pp 75–77 | Cite as

A case of malignant fibrous histiocytoma after breast conserving therapy for breast cancer

  • Rie Horii
  • Atushi Fukuuchi
  • Tsunehiro Nishi
  • Riichiro Takanashi
Case Report


A 45-year-old woman with malignant fibrous histiocytoma (MFH) of the breast following breast conserving therapy (BCT) is described.

She noticed a lump in her left breast 52 months after BCT for breast cancer. The lump was excised and nodular fasciitis was initially diagnosed. However, the tumor recurred locally 4 times in the next 18 months. MFH was finally diagnosed.

This case is considered to be radiation-induced sarcoma. The risk of radiation-induced sarcoma after BCT seems to be very low, however careful follow-up is necessary.

Key words

Malignant fibrous histiocytoma Radiation-induced sarcoma Breast conserving therapy 



Malignant fibrous histiocytoma


Breast conserving therapy


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  1. 1).
    Cahan WG, Woodard HQ, Higinbotham NL,et al: Sarcoma arising in irradiated bone.Cancer 1:3–29, 1948.CrossRefGoogle Scholar
  2. 2).
    Yamashita H: Radiation induced cancer.Gan-No-Rinsho 30:1595–1603, 1984.PubMedGoogle Scholar
  3. 3).
    Pendlebury SC, Bilous M, Langlands AO: Sarcomas following radiation therapy for breast cancer; A report of three cases and a review of the literature.Int J Radiat Oncol Biol Phys 31:405–410, 1995.PubMedGoogle Scholar
  4. 4).
    Pierce SM, Recht A, Lingos TI,et al: Long-term radiation complications following conservative surgery and radiation therapy in patients with early stage breast cancer.Int J Radiat Oncol Biol Phys 23:915–923, 1992.PubMedGoogle Scholar
  5. 5).
    Kurtz JM, Amalric R, Brandone H,et al: Contralateral breast cancer and other second malignancies in patients treated by breast-canserving therapy with radiation.Int J Radiat Oncol Biol Phys 15:277–284, 1988.PubMedCrossRefGoogle Scholar
  6. 6).
    Rubin E, Maddox WA, Mazur MT: Cutaneous angiosarcoma of the breast 7 years after lumpectomy and radiation therapy.Radiology 174:258–260, 1990.PubMedGoogle Scholar
  7. 7).
    Edeiken S, Russo DP, Knecht J,et al: Angiosarcoma after tylectomy and radiation therapy for carcinoma of the breast.Cancer 70:644–647, 1992.PubMedCrossRefGoogle Scholar
  8. 8).
    Stokkel MPM, Peterse HL: Angiosarcoma of the breast after lumpectomy and radiation therapy for adenocarcinoma.Cancer 69:2965–2968, 1992.PubMedCrossRefGoogle Scholar
  9. 9).
    Zucali R, Merson M, Placucci M,et al: Soft tissue sarcoma of the breast after conservative surgery and irradiation for early mammary cancer.Radiother Oncol 30:271–273, 1994.PubMedCrossRefGoogle Scholar
  10. 10).
    Del-Mastro L, Garrone O, Guenzi M,et al: Angiosarcoma of the residual breast after conservative surgery and radiotherapy for primary carcinoma.Ann Oncol 5:163–165, 1994.PubMedGoogle Scholar
  11. 11).
    Cafiero F, Gipponi M, Peressini A,et al: Radiationassociated angiosarcoma; Diagnostic and therapeutic implication-two case reports and a review of the literature.Cancer 77:2496–2502, 1996PubMedCrossRefGoogle Scholar
  12. 12).
    Wiklund TM, Blomqvist CP, Raty J,et al: Postirradiation sarcoma; Analysis of a nationwide cancer registry material.Cancer 68:534–531, 1991.CrossRefGoogle Scholar

Copyright information

© The Japanese Breast Cancer Society 2000

Authors and Affiliations

  • Rie Horii
    • 1
  • Atushi Fukuuchi
    • 1
  • Tsunehiro Nishi
    • 1
  • Riichiro Takanashi
    • 2
  1. 1.Departments of Breast and Endocrine SurgeryMitsui Memorial HospitalJapan
  2. 2.Departments of PathologyMitsui Memorial HospitalJapan

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