Ti Breast Cancer Associated with Von Recklinghausen’s Neurofibromatosis
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A rare case of breast cancer associated with von Recklinghausen’s neurofibromatosis is reported. This case and review of the literature illustrate the problems of clinical diagnosis.
A 66-year-old woman who had undergone sigmoidectomy for sigmoid colon cancer two years previously, was admitted to the hospital because of a left breast skin retraction in October, 1998. The patient had von Recklinghausen’s disease (neurofibromatosis type 1). The TNM clinical staging was TlcNOMO. Modified radical mastectomy was performed. The histopathological diagnosis of the breast tumor was invasive ductal carcinoma and the skin tumor was neurofibroma. The pTNM pathological staging was pTlcNlaMO.
Among patients similar to our case, almost all were staged higher than T2. This may be because multiple neurofibromas obscure breast mass at palpation, leading to delayed detection of the cancer. Systemic and careful exploration is essential for patients with von Recklinghausen’s neurofibromatosis to detect breast cancer at an early stage.
Key wordsBreast cancer Von Recklinghausen’s disease Neurofibromatosis
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- 4).Sorensen SA, Mulvihill JJ, Nielsen A: Long-term follow-up of von Recklinghausen neurofibromatosis; Survival and malignant neoplasms.N Engl] Med 314:1010–1015, 1986.Google Scholar
- 13).Sato R, Kimura Y, Kato E: A case of breast cancer associated with von Recklinghausen’'s disease.Jpn J Clin Surg 57:328–332, 1996(in Japanese with English abstract).Google Scholar
- 14).Osada K, Goto T, Taguchi T,et al: A case of breast cancer associated with von Recklinghausen’s disease.J Minami-Osaka Med 45:167–173, 1997(in Japanese with English abstract).Google Scholar
- 15).Sako H, Akashi I, Oita Y,et al: A case of intracystic carcinoma of the breast associated with von Recklinghausen’s disease.Med Postgraduates 35:64–67, 1997(in Japanese).Google Scholar
- 16).Suzuki A, Kameyama J, Sakai Y,et al: A rare case of double cancer of the breast and colon associated with von Recklinghausen’s disease.Jpn J Clin Surg 58:1396–1400, 1997(in Japanese with English abstract).Google Scholar