Breast Cancer

, Volume 6, Issue 3, pp 227–230 | Cite as

Ti Breast Cancer Associated with Von Recklinghausen’s Neurofibromatosis

  • Yoshihiko Murayama
  • Yutaka Yamamoto
  • Naoki Shimojima
  • Tetsuya Takahara
  • Kaichiro Kikuchi
  • Shuhei lida
  • Yasuko Kondo
Case Report


A rare case of breast cancer associated with von Recklinghausen’s neurofibromatosis is reported. This case and review of the literature illustrate the problems of clinical diagnosis.

A 66-year-old woman who had undergone sigmoidectomy for sigmoid colon cancer two years previously, was admitted to the hospital because of a left breast skin retraction in October, 1998. The patient had von Recklinghausen’s disease (neurofibromatosis type 1). The TNM clinical staging was TlcNOMO. Modified radical mastectomy was performed. The histopathological diagnosis of the breast tumor was invasive ductal carcinoma and the skin tumor was neurofibroma. The pTNM pathological staging was pTlcNlaMO.

Among patients similar to our case, almost all were staged higher than T2. This may be because multiple neurofibromas obscure breast mass at palpation, leading to delayed detection of the cancer. Systemic and careful exploration is essential for patients with von Recklinghausen’s neurofibromatosis to detect breast cancer at an early stage.

Key words

Breast cancer Von Recklinghausen’s disease Neurofibromatosis 


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Copyright information

© The Japanese Breast Cancer Society 1999

Authors and Affiliations

  • Yoshihiko Murayama
    • 1
  • Yutaka Yamamoto
    • 1
  • Naoki Shimojima
    • 1
  • Tetsuya Takahara
    • 1
  • Kaichiro Kikuchi
    • 1
  • Shuhei lida
    • 1
  • Yasuko Kondo
    • 2
  1. 1.Department of SurgeryNerima General HospitalJapan
  2. 2.Departments of PathologyNerima General HospitalJapan

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