Breast Cancer

, Volume 3, Issue 2, pp 125–129 | Cite as

Angiosarcoma of the breast: Immunohistochemical demonstration of steroid receptors and literature review

  • Yogendra Singh
  • Kentaro Inoue
  • Hiroshi Kawanishi
  • Koshiro Hioki
  • Takeshi Horio
  • Nobuaki Shikata
  • Yoshiko Uemura
  • Airo Tsubura
Case Report


A 44-year-old female with bilateral angiosarcoma of the breast with multiple skin metastases is reported. She presented with a 6 × 8 cm and 1 × 1 cm mass in her left and right breasts, respectively, and multiple skin lesions around the chest. Histologically, the excised tumor was diagnosed as angiosarcoma of the breast with skin metastasis. Tumor cells were immunohistochemically positive with factor VIII-related antigen, CD34, α-smooth muscle actin and vimentin, and positive with UEA-I lectin. The majority of tumor cell nuclei expressed progesterone receptor (PgR) protein but estrogen receptor (ER) protein and androgen receptor (AR) protein were negative. According to the literature, angiosarcoma of the breast mostly affects females in their fourth (33%) and fifth (40%) decades (mean age, 39.5 ± 10.7 years). The survival rate depends on tumor size and tumor differentiation. The 3-year survival rate is 86% in patients with a tumor size less than 5 cm, and 90% in well-differentiated group I lesions.

Key words

Breast Angiosarcoma Estrogen receptor Progesterone receptor Immunohistochemistry 



Estrogen receptor


Progesterone receptor


Androgen receptor


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  1. 1).
    Enzinger FM, Weiss SW: Malignant vascular tumors. In: Soft Tissue Tumor, Mosby, St Louis, pp422–449, 1983.Google Scholar
  2. 2).
    Rosen PP, Oberman HA: Angiosarcoma. In: Tumor of the Mammary Gland, AFIP, Washington DC, pp320–328, 1992.Google Scholar
  3. 3).
    Oyaizu T, Arita S, Hatano T,et al: Immunohistochemical detection of estrogen and progesterone receptors performed with an antigen-retrieval technique on methacarn-fixed paraffin-embedded breast cancer tissue.J Surg Res 60:69–73, 1996.PubMedCrossRefGoogle Scholar
  4. 4).
    Shikata N, Kurokawa I, Andachi H,et al: Expression of androgen receptors in skin appendage tumors; An immunohistochemical study.J Cutan Pathol 22:149–153, 1995.PubMedCrossRefGoogle Scholar
  5. 5).
    Schmidt GB: Veber das Angiosarkom der Mamma.Arch Klin Chir 36:421–427, 1887.Google Scholar
  6. 6).
    Rainwater LM, Martin JK, Gaffey TA,et al: Angiosarcoma of the breast.Arch Surg 121:669–672, 1986.PubMedGoogle Scholar
  7. 7).
    Rosen PP, Kimmel M, Ernsberger D: Mammary angiosarcoma; The prognostic significance of tumor differentiation.Cancer 62:2145–2151, 1988.PubMedCrossRefGoogle Scholar
  8. 8).
    Brentani MM, Pacheco MM, Oshima CTF,et al: Steroid receptors in breast angiosarcoma.Cancer 51: 2105–2111, 1983.PubMedCrossRefGoogle Scholar
  9. 9).
    Weiss SW, Langloss JM, Shmookler BM,et al: Estrogen receptor protein in bone and soft tissue tumors.Lab Invest 54:689–694, 1986.PubMedGoogle Scholar
  10. 10).
    Chaudhuri PK, Walker MJ, Beattie CW,et al: Presence of steroid receptors in human soft tissue sarcomas of diverse histological origin.Cancer Res 40: 861–865, 1980.PubMedGoogle Scholar
  11. 11).
    Anderson C, Ricci A, Pedersen CA,et al: Immunocytochemical analysis of estrogen and progesterone receptors in benign stromal lesions of the breast.Am J Surg Pathol 15:145–149, 1991.PubMedGoogle Scholar
  12. 12).
    Donnel RM, Rosen PP, Lieberman PH,et al: Angiosarcoma and other vascular tumors of the breast.Am J Surg Pathol 5:629–642, 1981.Google Scholar
  13. 13).
    Merino MJ, Berman M, Carter D: Angiosarcoma of the breast.Am J Surg Pathol 7:53–60, 1983.PubMedCrossRefGoogle Scholar
  14. 14).
    Chen KTK, Kirkegaard DD, Bocian JJ: Angiosarcoma of the breast.Cancer 46:368–371, 1980.PubMedCrossRefGoogle Scholar
  15. 15).
    Britt LD, Lambert P, Sharma R,et al: Angiosarcoma of the breast; Initial misdiagnosis is still common.Arch Surg 130:221–223, 1995.PubMedGoogle Scholar
  16. 16).
    Antman KH, Corson J, Greenberger J,et al: Multimodality therapy in the management of angiosarcoma of the breast.Cancer 50:2000–2003, 1982.PubMedCrossRefGoogle Scholar
  17. 17).
    Hunter TB, Martin PC, Dietzen CD,et al: Angiosarcoma of the breast; Two case reports and a review of the literature.Cancer 56:2099–2106, 1985.PubMedCrossRefGoogle Scholar
  18. 18).
    Khosim M, Sadiq S, Ajarim D,et al: Bilateral angiosarcoma of the breast; A case report.Jpn J Surg 21:693–695, 1991.CrossRefGoogle Scholar

Copyright information

© The Japanese Breast Cancer Society 1996

Authors and Affiliations

  • Yogendra Singh
    • 1
    • 3
  • Kentaro Inoue
    • 1
  • Hiroshi Kawanishi
    • 1
  • Koshiro Hioki
    • 1
  • Takeshi Horio
    • 2
  • Nobuaki Shikata
    • 3
  • Yoshiko Uemura
    • 3
  • Airo Tsubura
    • 3
  1. 1.Department of SurgeryKansai Medical UniversityMoriguchiJapan
  2. 2.Department of DermatologyKansai Medical UniversityMoriguchiJapan
  3. 3.Department of PathologyKansai Medical UniversityMoriguchiJapan

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