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Breast Cancer

, Volume 3, Issue 2, pp 125–129 | Cite as

Angiosarcoma of the breast: Immunohistochemical demonstration of steroid receptors and literature review

  • Yogendra Singh
  • Kentaro Inoue
  • Hiroshi Kawanishi
  • Koshiro Hioki
  • Takeshi Horio
  • Nobuaki Shikata
  • Yoshiko Uemura
  • Airo Tsubura
Case Report

Abstract

A 44-year-old female with bilateral angiosarcoma of the breast with multiple skin metastases is reported. She presented with a 6 × 8 cm and 1 × 1 cm mass in her left and right breasts, respectively, and multiple skin lesions around the chest. Histologically, the excised tumor was diagnosed as angiosarcoma of the breast with skin metastasis. Tumor cells were immunohistochemically positive with factor VIII-related antigen, CD34, α-smooth muscle actin and vimentin, and positive with UEA-I lectin. The majority of tumor cell nuclei expressed progesterone receptor (PgR) protein but estrogen receptor (ER) protein and androgen receptor (AR) protein were negative. According to the literature, angiosarcoma of the breast mostly affects females in their fourth (33%) and fifth (40%) decades (mean age, 39.5 ± 10.7 years). The survival rate depends on tumor size and tumor differentiation. The 3-year survival rate is 86% in patients with a tumor size less than 5 cm, and 90% in well-differentiated group I lesions.

Key words

Breast Angiosarcoma Estrogen receptor Progesterone receptor Immunohistochemistry 

Abbreviations

ER

Estrogen receptor

PgR

Progesterone receptor

AR

Androgen receptor

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Copyright information

© The Japanese Breast Cancer Society 1996

Authors and Affiliations

  • Yogendra Singh
    • 1
    • 3
  • Kentaro Inoue
    • 1
  • Hiroshi Kawanishi
    • 1
  • Koshiro Hioki
    • 1
  • Takeshi Horio
    • 2
  • Nobuaki Shikata
    • 3
  • Yoshiko Uemura
    • 3
  • Airo Tsubura
    • 3
  1. 1.Department of SurgeryKansai Medical UniversityMoriguchiJapan
  2. 2.Department of DermatologyKansai Medical UniversityMoriguchiJapan
  3. 3.Department of PathologyKansai Medical UniversityMoriguchiJapan

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