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Breast Cancer

, Volume 3, Issue 2, pp 79–92 | Cite as

Phyllodes tumor of the breast: Pathology, histogenesis, diagnosis, and treatment

  • Shinzaburo Noguchi
  • Tomohiko Aihara
  • Kazuyoshi Motomura
  • Hideo Inaji
  • Shingi Imaoka
  • Hiroki Koyama
  • Tsutomu Kasugai
  • Akira Wada
Review Article

Abstract

Phyllodes tumor of the breast is histologically unique in that it is composed of epithelial and stromal components. The histogenesis of this disease has remained largely unknown but recently we have obtained interesting information through clonal analysis, and have been able to show a difference in the histogenesis between phyllodes tumor and fibroadenoma. Elucidation of histogenesis would definitely improve our understanding of the biological behavior of this disease and also help to establish the most appropriate treatment strategy. The pathology, histogenesis, diagnosis, and treatment of phyllodes tumor are reviewed in this paper. Our hypothesis on the histogenesis of this disease is also presented.

Key words

Phyllodes tumor Fibroadenoma Clonality 

Abbreviations

AR

Androgen receptor

bp

Base pairs

FNAB

Fine needle aspiration biopsy

PCR

Polymelase chain reaction

PGK

Phosphoglycerokinase

RFLP

Restriction fragment length polymorphism

Xm

Maternal X-chromosome

Xp

Paternal X-chromosome

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Copyright information

© The Japanese Breast Cancer Society 1996

Authors and Affiliations

  • Shinzaburo Noguchi
    • 1
  • Tomohiko Aihara
    • 1
  • Kazuyoshi Motomura
    • 1
  • Hideo Inaji
    • 1
  • Shingi Imaoka
    • 1
  • Hiroki Koyama
    • 1
  • Tsutomu Kasugai
    • 2
  • Akira Wada
    • 2
  1. 1.Departments of SurgeryOsaka Medical Center for Cancer and Cardiovascular DiseasesJapan
  2. 2.Departments of PathologyOsaka Medical Center for Cancer and Cardiovascular DiseasesHigashinari-ku, OsakaJapan

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