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Breast Cancer

, Volume 5, Issue 3, pp 309–312 | Cite as

Primary non-hodgkin’s lymphoma of the breast: a report of two cases

  • Eiji Hinoshita
  • Hideya Tashiro
  • Ikuo Takahashi
  • Toshihiro Onohara
  • Takashi Nishizaki
  • Toshimitsu Matsusaka
  • Kenzo Wakasugi
  • Tetsuo Ishikawa
  • Kazuhiro Kume
  • Ichiro Yamamoto
  • Yuichi Hirota
Case Report

Abstract

Background: Primary non-Hodgkin’s lymphoma of the breast (PBNHL) is a rare neoplasm and PBNHL occuring in a man is extremely rare.

Method: We report herein two cases of PBNHL and discuss methods of diagnosis and treatment.

Results: The first patient was a 35-year-old woman who presented with an elastic-hard mass in her left breast and adenopathy in her left axillary fossa. Mammography and ultrasonography suggested left breast cancer. Frozen sections demonstrated PBNHL histologically. Quadrantectomy of the breast was performed followed by chemotherapy. The second patient was a 65-year-old man with an elastic-hard mass in his left breast and left axillary lymphadenopathy. Mammography and ultrasonography suggested breast cancer or a soft tissue tumor. Intraoperative histological examination revealed a diagnosis of non-Hodgkin’s lymphoma (NHL). A simple mastectomy and postoperative chemotherapy were performed and the patient had a good prognosis.

Conclusion: A multidisciplinary approach including surgery, chemotherapy, and radiotherapy is indispensable in treating PBNHL, after diagnosis by excisional biopsy or aspiration cytology.

Key words

Non-Hodgkin’s lymphoma Breast neoplasm 

Abbreviations

PBNHL

Primary non-Hodgkin’s lymphoma of the breast

NHL

Non-Hodgkin’s lymphoma

CEA

Carcino-embryonic antigen

CA15-3

Carcinogenic antigen 15-3

ADM

Adriamycin

CPA

Cyclophosphamide

VCR

Vincristine

PSL

Prednisolone

MTX

Methotrexate

VP-16

Etoposide

6-MP

6-Mercaptopurine

SPECT

Single positron emisson computed tomography

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Copyright information

© The Japanese Breast Cancer Society 1998

Authors and Affiliations

  • Eiji Hinoshita
    • 1
  • Hideya Tashiro
    • 2
  • Ikuo Takahashi
    • 2
  • Toshihiro Onohara
    • 2
  • Takashi Nishizaki
    • 2
  • Toshimitsu Matsusaka
    • 2
  • Kenzo Wakasugi
    • 2
  • Tetsuo Ishikawa
    • 2
  • Kazuhiro Kume
    • 2
  • Ichiro Yamamoto
    • 3
  • Yuichi Hirota
    • 4
  1. 1.Department of Surgery II, Faculty of MedicineKyushu UniversityFukuokaJapan
  2. 2.Department of SurgeryMatsuyama Red Cross HospitalJapan
  3. 3.Department of PathologyMatsuyama Red Cross HospitalJapan
  4. 4.Department of Internal MedicineMatsuyama Red Cross HospitalJapan

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