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Breast Cancer

, Volume 4, Issue 4, pp 210–212 | Cite as

Multidrug resistance and prodrug activation for cancer gene therapy of breast cancer

  • Taruma Fujii
  • S. Q. Fu
  • L. H. Yin
  • T. Nanakorn
  • Felix Garcia Sanchez
  • Matt Cooperberg
  • David Guo
  • Twang Lin D.
  • Giuseppe Pizzorno
  • Albert Deisseroth
Article
  • 30 Downloads

Abstract

Current approaches to the treatment of cancer (radiation and chemotherapy) are limited by the toxicity to normal tissues and the sensitivity of tumor cells to these treatments. The use of gene delivery vector systems for the introduction of genetic elements into normal and neoplastic tissues which code for proteins that protect the normal chemotherapy-sensitive tissues and sensitize the tumor cells to radiation and chemotherapy, may contribute to an overall improvement in the outcome of cancer treatment programs. This chapter will review the clinical trials either completed or about to be initiated which are designed to accomplish these goals.

Keywords

Chemotherapy resistance Chemotherapy sensitivity Gene therapy 

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Copyright information

© The Japanese Breast Cancer Society 1997

Authors and Affiliations

  • Taruma Fujii
    • 1
  • S. Q. Fu
    • 1
  • L. H. Yin
    • 1
  • T. Nanakorn
    • 1
  • Felix Garcia Sanchez
    • 1
  • Matt Cooperberg
    • 1
  • David Guo
    • 1
  • Twang Lin D.
    • 1
  • Giuseppe Pizzorno
    • 1
  • Albert Deisseroth
    • 1
  1. 1.Genetic Therapy Program of the Yale Cancer Center and the Medical Oncology Section, Department of Internal MedicineYale University School of MedicineNew Haven

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