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Effet comparatif de deux inhibiteurs de la pompe à protons (IPP) (Lansoprazole et Pantoprazole) en pH-métrie gastrique des 24 heures chez le sujet sain

Comparative trial of 2 proton-pump inhibitors (Lansoprazole and Pantoprazole) on 24 h pH gastric profile in healthy volunteers

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Acta Endoscopica

Conclusion

Le lansoprazole (30 mg) a modifié le pH-gastrique de façon significativement plus prolongée que le pantoprazole sur 24 heures aussi bien à J1 qu’à J7. L’activité antisécrétoire du lansoprazole était maximale dès la première prise, alors que celle du pantoprazole augmentait significativement de J1 à J7.

Conclusion

Lansoprazole (30 mg) was significantly more potent than pantoprazole on 24 hours pH profile either on D1 and D7. Antisecretory effect of lansoprazole was maximum from the 1st intake whereas pantoprazole activity increased significantly from D1 to D7.

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Références

  1. BRULEY DES VARANNES S., LEVY P., LARTIGUE S.et al. — Comparison of lansoprazole with omeprazole on 24 hour intragastric pH, acid secretion and serum gastrin in healthy volunteers.Aliment. Pharmacol. Ther., 1994,8, 309–314.

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  2. HARTMANN M. — Comparison of the 24 h intragastric pH profiles following single and repeated oral intake of pantoprazole 40 mg and omeprazole 20 mg in healthy male volunteers.Gastroenterology, 1993,104, A95.

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Author notes

  1. C. Florent

    Present address: Hôpital Saint-Antoine, Service de Gastroentérologie, 184, rue du Faubourg Saint-Antoine, 75475, Paris Cedex 12

Authors and Affiliations

  1. Laboratoires Takeda, Puteaux, France

    S. Forestier

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  1. C. Florent
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  2. S. Forestier
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Florent, C., Forestier, S. Effet comparatif de deux inhibiteurs de la pompe à protons (IPP) (Lansoprazole et Pantoprazole) en pH-métrie gastrique des 24 heures chez le sujet sain. Acta Endosc 26, 135–136 (1996). https://doi.org/10.1007/BF02965799

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  • DOI: https://doi.org/10.1007/BF02965799

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