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Les altérations histologiques observées au cours de la surveillance de l’endobrachyœsophage

The histologic alterations observed in the course of surveillance of Barrett’s esophagus

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Acta Endoscopica

RéSUMé

Diverses modifications épithéliales s’observent sur l’épithélium de Barrett, qui est lui-même une métaplasie post-inflammatoire. Les modifications les plus importantes sont les remaniements néoplasiques, en raison de leurs implications importantes du point de vue diagnostique, surveillance et pronostic. Le diagnostic d’une dysplasie de faible degré est souvent difficile, en raison du manque de clarté de la distinction histologique entre dysplasic véritable et épithélium régénératif pseudodysplasique. Dès lors, le concept d’épithélium « en dysplasie indéterminée » a nettement évolué. Chaque biopsie prélevée sur une muqueuse d’épithélium de Barrett a des implications sur la conduite de la surveillance, qui va du simple suivi de l’épithélium néoplasique à la surveillance stricte qui concerne les états allant de l’épithélium indéterminé à la résection pour carcinome.

Summary

A variety of epithelial changes occur in Barren’s mucosa, which itself is a posl- inflammatory metaplasia. The most important of these are the neoplastic alterations, including the dysplasias and carcinomas, because they have significant implications in terms of management and prognosis. The diagnosis of low grade dysplasia is often difficult, because the histologie distinction between true dysplasia and dysplasia- like regenerative epithelium is not always clear. Thus the concept of epithelium « indefinite for dysplasia » has evolved. Every biopsy of a Barrett’s mucosa carries with it implications for patient management which vary from simple follow- up for non-neoplastic epithelium to rigorous surveillance for indefinite epithelium to resection for carcinoma.

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Références

  1. ALTORKI N.K., SUNAGAWA M., LITTLE A.G., SKINNER D.B. - High-grade dysplasia in the columnarlined esophagus.Am. J. Surg., 1991,161, 97–99.

    Article  PubMed  CAS  Google Scholar 

  2. APPELMAN H.D. - Barrett’s esophagus: morphologic considerations, in ORRINGER MB [ed], Shackelford’s Surgery of the Alimentary Tract, Volume I, The Esophagus, Philadelphia, WB Saunders Company, 1991, 314–330.

    Google Scholar 

  3. BURKE A.P. SOBIN L.H. SHEKITKA K.M., HELWIG E.B. - Dysplasia of the stomach and Barrett esophagus: a follow-up study.Mod. Palhol., 1991,4, 336–341.

    CAS  Google Scholar 

  4. CAMERON A.J., ZINMEISTER A.R., BALLARD D.J., CARNEY J.A. - Prevalence of columnar-lined [Barrett’s] esophagus.Gastroenterol., 1990,99, 918–922.

    CAS  Google Scholar 

  5. FENNERTY M.B., SAMPLINER R.E., WAY D.et al. - Discordance between flow cytometric abnormalities and dysplasia in Barrett’s esophagus.Gastroenterol., 1989,97, 815–820.

    CAS  Google Scholar 

  6. HAGGITT R.C., DEAN P.J. - Adenocarcinomas in Barrett’s épithélium, in SPECHLER SJ and GOYAL RK [eds]: Barrett’s Esophagus : Pathophysiology, Diagnosis, and Management. New York, Elsevier, 1985, 153–166.

    Google Scholar 

  7. HAGGITT R.C., REID B.J., RABINOVITCH P.S., RUBIN C.E. - Barrett’s esophagus. Correlation between mucin histochemistry, flow cytometry, and histologic diagnosis for predicting increased cancer risk.Am. J. Palhol., 1988,131, 53–61.

    CAS  Google Scholar 

  8. HAMEETEMAN W., TYTGAT G.N.J., HOUTGOFF H.J., VAN DEN TWEEL J.G. -Barrett’s esophagus: development of dysplasia and adenocarcinoma.Gastroenterol., 1989,96, 1249–1256.

    CAS  Google Scholar 

  9. HAMILTON S.R. - Reflux esophagitis and Barrett esophagus, in Goldman H, Appelman HD and Kaufman N, [eds] : Gastrointestinal Pathology, Baltimore, Williams and Wilkins, 1990, 39–42.

  10. HAMILTON S.R., SMITH R.R. - The relationship between columnar epithelial dysplasias and invasive adenocarcinoma arising in Barrett’s esophagus.Am. J. Clin. Pathol., 1987,87, 301–312.

    PubMed  CAS  Google Scholar 

  11. JAMES P.D., ATKINSON M. - Value of DNA image cytometry in the prediction of malignant change in Barrett’s œsophagus.Gut, 1989,30, 899–905.

    Article  PubMed  CAS  Google Scholar 

  12. MCKINLEY M.J., BUDMAN D.R., GRUENEBERG D.et al.- DNA content in Barrett’s esophagus and esophageal malignancy.Am. J. Gastroenterol., 1987,82, 1012- 1015.

    PubMed  CAS  Google Scholar 

  13. NISHIMAKI T., HOLSCHER A.H., SCHULER M.,el al.- Histopathologic characteristics of early adenocarcinoma in Barrett’s esophagus.Cancer, 1991,68, 1731–1736.

    Article  PubMed  CAS  Google Scholar 

  14. PALLEY S.L., SAMPLINER R.E., GAREWAL H.S. - Editorial: management of high-grade dysplasia in Barrett’s esophagus.J. Clin. Gastroenterol., 1989,11, 369–372.

    Article  PubMed  CAS  Google Scholar 

  15. REID B.J., HAGGITT R.C., RUBIN C.E.,et al.- Observer variation in the diagnosis of dysplasia in Barrett’s esophagus.Hum. Pathol., 1988,19, 166–178.

    Article  PubMed  CAS  Google Scholar 

  16. REID B.J., WEINSTEIN W.M., LEWIN K.J.et al. - Endoscopic biopsy can detect high-grade dysplasia or early adenocarcinoma in Barrett’s esophagus without grossly recognizable neoplastic lesions.Gastroenterol., 1988,94, 81–90.

    CAS  Google Scholar 

  17. RIDDELL R.H. - Dysplasia and regression in Barrett’s épithélium. In SPECHLER SJ and GOYAL RK [eds]. Barrett’s Esophagus: Pathophysiology, Diagnosis and Management. New York, Elsevier, 1985, 143–152.

    Google Scholar 

  18. RIDDELL R.H., GOLDMAN H., RANSOHOFF D.F.et al. - Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications.Hum. Pathol., 1983,14, 931–968.

    Article  PubMed  CAS  Google Scholar 

  19. ROBERTSON C.S., MAYBERRY J.F., NICHOLSON D.A.et al. - Value of endoscopie surveillance in the detection of neoplastic change in Barrett’s œsophagus.Br. J. Surg., 1988,75, 760–763.

    Article  PubMed  CAS  Google Scholar 

  20. ROSENGARD A.M., HAMILTON S.R. - Squamous carcinoma of the esophagus in patients with Barrett esophagus.Mod. Pathol., 1989,2, 2–7.

    PubMed  CAS  Google Scholar 

  21. RUBIO C.A., ABERG B. - Barrett’s mucosa in conjunction with squamous carcinoma of the esophagus.Cancer 1991,68, 583–586.

    Article  PubMed  CAS  Google Scholar 

  22. SPECHLER S.J., GOYAL R.K. - Barrett’s esophagus.N. Engl. J. Med., 1986,315, 362–371.

    PubMed  CAS  Google Scholar 

  23. WILLIAMSON W.A., ELLIS F.H., GIBB S.P.et al. - Barrett’s esophagus. Prevalence and incidence of adenocarcinoma.Arch. Intern. Med., 1991,151, 2212–2216.

    Article  PubMed  CAS  Google Scholar 

  24. WINTERS C. Jr. SPURLING T.J., CHOBANIAN S.J. J.et al. - Barrett’s esophagus. A prevalent, occult complication of gastroesophageal reflux disease.Gastroenterol., 1987,92, 118–124.

    Google Scholar 

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Appelman, H.D. Les altérations histologiques observées au cours de la surveillance de l’endobrachyœsophage. Acta Endosc 22, 517–530 (1992). https://doi.org/10.1007/BF02965115

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