Mycotoxin Research

, Volume 21, Issue 3, pp 164–167 | Cite as

Ochratoxin A blood concentration in healthy subjects and bladder cancer cases from Pakistan

  • M. Aslam
  • A.E. Beg
  • M. Blaszkewicz
  • G. H. Degen
  • K. Golka


The mycotoxin ochratoxin A (OTA) is a public health issue in many countries. Data on OTA concentrations in foods and in blood are available for several European countries including the Balkan area, as well as for Canada and Japan. Yet, for developing countries such data are scarce. In this study we determined OTA blood levels as biomarker of exposure in bladder cancer patients and in healthy controls from Pakistan. OTA in blood was analyzed after extraction by HPLC with fluorescence detection (limit of detection: <0.03 ng/mL) in 96 patients and in 31 controls. Over 92% of all blood samples (87 patients, 30 controls) contained quantifiable amounts of OTA: The mean OTA concentrations were 0.33 ng/mL (SD 0.42; range: 0.03 to 3.41 ng/mL) in bladder cancer patients, and 0.31 ng/mL (SD 0.29; range: 0.04 to 1.25 ng/mL) in healthy controls. These OTA concentrations are comparable to those reported for the general population in the European Union.


biomarker of exposure ochratoxin A Pakistan 


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Copyright information

© Society of Mycotoxin Research and Springer 2005

Authors and Affiliations

  • M. Aslam
    • 1
  • A.E. Beg
    • 1
  • M. Blaszkewicz
    • 2
  • G. H. Degen
    • 2
  • K. Golka
    • 2
  1. 1.Department of PharmaceuticsUniversity of KarachiKarachiPakistan
  2. 2.Institute for Occupational Physiology at the University of DortmundDortmundGermany

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