The action of tolbutamide on rat diaphragm

  • J. J. Connon


PHYSIOLOGICAL concentrations of tolbutamide increased glucose uptake by the rat hemidiaphragm. The increase was not affected by excess insulin neutralising serum and although decreased by 0.006/M cysteine was still significantly greater than the basal uptake. These results suggest that the action of tolbutamide on glucose uptake is independent of insulin.


  1. Aiman, R., and Chaudray, N. (1959). Brit. J. Pharmacol., 12. 377.Google Scholar
  2. Cahill, G. F., Hastings, A. B., and Ashmore, J. (1957). Diabetes, 6, 26.PubMedCrossRefGoogle Scholar
  3. Canal, N., Garattini, S., and Tessari, L. (1956). Boll. soc. Ital. Biol. sper., 32, 491.PubMedGoogle Scholar
  4. Caren, R., and Corbo, L. (1957). J. clin. Invest., 36, 1546.PubMedCentralPubMedCrossRefGoogle Scholar
  5. Chu, Ping-Chi, Conway, M. J., Krouse, H. A., and Goodner, C. J. (1968). Ann. intern. Med., 68, 758.CrossRefGoogle Scholar
  6. Clarke, D. W., Davidson, M., Schonbaum, E., and Senman, H. (1956). Canad. med. Ass. J., 74, 966.PubMedCentralPubMedGoogle Scholar
  7. Fajans, S. S., and Conn, J. W. (1956). Metabolism, 5, 820.PubMedGoogle Scholar
  8. Field, J. B., and Woodson, M. L. (1956). Proc. Soc. exp. Biol. (N.Y.), 93, 534.CrossRefGoogle Scholar
  9. Fry, I. K. and Wright, P. H. (1957). Brit. J. Pharmacol., 12, 350.PubMedCentralPubMedGoogle Scholar
  10. Goetz, F. C., Gilbertson, A., and Josephson, V. (1956). Metabolism, 5, 788.PubMedGoogle Scholar
  11. Grodsky, G. M., Bennett, L. L., Smith, D., and Nemechek, K. (1967). Brook Lodge Lodge Symposium, Augusta, Michigan.Google Scholar
  12. Houssay, B. A., Penhos, J. C., Urgoiti, E., Theodosio, N., Apelbaum, J., and Bowkett, J. (1967). Ann. N.Y. Acad. Sci., 71, 25.CrossRefGoogle Scholar
  13. Loubatieres, A. (1957). Diabetes, 6, 408.PubMedCrossRefGoogle Scholar
  14. Mohnike, G., Knitsch, K. W., Boser, H., Werner, G., and Werner, S. (1957). Dtsch. Med. Wschr., 82, 1580.PubMedCrossRefGoogle Scholar
  15. Pletscher, A., and Gey, K. F. (1957). Experientia, 13, 447.PubMedCrossRefGoogle Scholar
  16. Rafaelson, O. J. (1959). Metabolism, 8, 195.Google Scholar
  17. Randle, P. J. (1954). Brit. med. J. 1, 1237.PubMedCentralPubMedCrossRefGoogle Scholar
  18. Root, M. A. (1957a). Diabetes, 6, 12.PubMedCrossRefGoogle Scholar
  19. Root, M. A. (1957b). J. Pharmacol., 119. 468.Google Scholar
  20. Vallance-Owen, J., Jolpin, C. F., and Fraser, R. (1959). Lancet, 2, 584.PubMedCrossRefGoogle Scholar
  21. Vallance-Owen, J., and Hurlock, B. (1954). Lancet, 1, 68.CrossRefGoogle Scholar
  22. Yalow, R. S., Black, H., Willazon, M., and Berson, S. A. (1960). Diabetes, 9, 356.PubMedCrossRefGoogle Scholar

Copyright information

© Springer 1969

Authors and Affiliations

  • J. J. Connon
    • 1
  1. 1.The Department of MedicineThe Queen’s University of BelfastBelfastUK

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