The action of tolbutamide on rat diaphragm
PHYSIOLOGICAL concentrations of tolbutamide increased glucose uptake by the rat hemidiaphragm. The increase was not affected by excess insulin neutralising serum and although decreased by 0.006/M cysteine was still significantly greater than the basal uptake. These results suggest that the action of tolbutamide on glucose uptake is independent of insulin.
- Aiman, R., and Chaudray, N. (1959). Brit. J. Pharmacol., 12. 377.Google Scholar
- Grodsky, G. M., Bennett, L. L., Smith, D., and Nemechek, K. (1967). Brook Lodge Lodge Symposium, Augusta, Michigan.Google Scholar
- Rafaelson, O. J. (1959). Metabolism, 8, 195.Google Scholar
- Root, M. A. (1957b). J. Pharmacol., 119. 468.Google Scholar