The pathobiology of lost human potential: Schizophrenia as a neurodevelopmental disorder

  • John L. Waddington


Influenza Schizophrenia Temporal Lobe Temporal Lobe Epilepsy Neurodevelopmental Disorder 
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  1. 1.
    Holmquist, K. Schizophrenia: the suffering and the stigma. The Irish Times 1988, Oct. 8: Suppl. 1–2.Google Scholar
  2. 2.
    American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 3rd rev. ed. Washington DC: American Psychiatric Association, 1987.Google Scholar
  3. 3.
    National Advisory Mental Health Council. Schizophrenia: the disorder and its scope. In: National Advisory Mental Health Council. A national plan for schizophrenia research. Rockville: U.S. Department of Health and Human Services, 1989: 1–2.Google Scholar
  4. 4.
    Bradbury, T. N., Miller, G. A. Season of birth of schizophrenia: a review of evidence, methodology and etiology. Psychol. Bull. 1985: 98. 569–594.PubMedCrossRefGoogle Scholar
  5. 5.
    O’Callaghan, E., Gibson, T., Colohan, H. A., Walshe, D., Buckley, P., Larkin, C., Waddington, J. L. Season of birth in schizophrenia: evidence for confinement of an excess of winter births to patients without a family history of mental disorder. Brit. J. Psychiat. 1991: 158, 764–769.PubMedGoogle Scholar
  6. 6.
    Lewis, S. W., Murray, R. M. Obstetric complications, neurodevelopmental deviance and risk of schizophrenia. J. Psychiat. Res. 1987: 21, 413–421.PubMedCrossRefGoogle Scholar
  7. 7.
    McNeil, T. F. Obstetric complications in schizophrenic parents. Schiz. Res. 1991: 5, 89–101.CrossRefGoogle Scholar
  8. 8.
    Mednick, S. A., Machon, R. A., Huttenen, M. O., Bonet, D. Adult schizophrenia following prenatal exposure to an influenza epidemic. Arch Gen. Psychiat. 1988: 45, 189–192.PubMedGoogle Scholar
  9. 9.
    O’Callaghan, E., Sham, P., Takei, N., Glover, G., Murray, R. M. Schizophrenia after prenatal exposure to 1957 A2 influenza epidemic. Lancet 1991: 337, 1248–1250.PubMedCrossRefGoogle Scholar
  10. 10.
    Murray, R. M., Lewis, S. W. Is schizophrenia a neurodevelopmental disorder? Brit. Med. J. 1987: 295, 681–682.Google Scholar
  11. 11.
    Weinberger, D. R. Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen. Psychiat. 1987: 44, 660–669.PubMedGoogle Scholar
  12. 12.
    Waddington, J. L. The ageing brain, neuroleptic drugs and the enigma of schizophrenia. Irish J. Med. Sci. 1988: 157, 135–141.PubMedCrossRefGoogle Scholar
  13. 13.
    Lyons, M., Barr, C. E., Cannon, T. D., Mednick, S. A., Shore, D. Fetal neural development and schizophrenia. Schiz. Bull. 1989: 15, 149–161.Google Scholar
  14. 14.
    Waddington, J. L. Sight and insight: regional cerebral metabolic activity in schizophrenia visualised by positron emission tomography, and competing neurodevelopmental perspectives. Brit. J. Psychiat. 1990: 156, 615–619.PubMedCrossRefGoogle Scholar
  15. 15.
    Waddington, J. L., Torrey, E. F. Schizophrenia, neurodevelopment and disease. Arch Gen. Psychiat. 1991: 48, 271–273.PubMedGoogle Scholar
  16. 16.
    Walker, E., Lewine, R. J. Prediction of adult-onset schizophrenia from childhood home movies of the patients. Amer. J. Psychiat. 1990: 147, 1052–1056.PubMedGoogle Scholar
  17. 17.
    Fish, B. Infant predictors of the longitudinal course of schizophrenic development. Schiz. Bull. 1987: 13, 395–409.Google Scholar
  18. 18.
    Crow, T. J. Temporal lobe asymmetries as the key to the etiology of schizophrenia. Schiz. Bull. 1990: 16, 433–443.Google Scholar
  19. 19.
    Torrey, E. F. A viral-anatomical explanation of schizophrenia. Schiz. Bull. 1991: 17, 15–18.Google Scholar
  20. 20.
    Torrey, E. F., McGuire, M., O’Hare, A., Walsh, D., Spellman, M. P. Endemic psychosis in western Ireland. Amer. J. Psychiat. 1984: 141, 966–970.PubMedGoogle Scholar
  21. 21.
    Sartorius, N., Jablensky, A., Korten, A., Ernberg, G., Anker, M., Cooper, J. E., Day, R. Early manifestations and first contact incidence of schizophrenia in different cultures. Psychol. Med. 1986: 16, 909–928.PubMedGoogle Scholar
  22. 22.
    NiNuallain, M., O’Hare, A., Walsh, D. Incidence of schizophrenia in Ireland. Psychol. Med. 1987: 17, 943–948.PubMedGoogle Scholar
  23. 23.
    Youssef, H. A., Kinsella, A., Waddington, J. L. Evidence for geographical variations in the prevalence of schizophrenia in rural Ireland. Arch Gen. Psychiat. 1991: 48, 254–258.PubMedGoogle Scholar
  24. 24.
    Waddington, J. L., Youssef, H. A. Geographical variations in the prevalence of schizophrenia in rural Ireland? Arch Gen. Psychiat. (in press).Google Scholar
  25. 25.
    NiNuallain, M., O’Hare, A., Walsh, D. The prevalence of schizophrenia in three counties in Ireland. Acta Psychiat. Scand. 1990: 82, 136–140.CrossRefGoogle Scholar
  26. 26.
    Torrey, E. F. Geographical distribution of insanity in America: evidence for an urban factor. Schiz. Bull. 1990: 16, 591–604.Google Scholar
  27. 27.
    Torrey, E. F. Schizophrenia: fixed incidence or fixed thinking? Psychol. Med. 1989: 19, 285–287.PubMedGoogle Scholar
  28. 28.
    Smith, D. W. Recognizable patterns of human malformation. Philadelphia: W. B. Saunders, 1976.Google Scholar
  29. 29.
    Green, M. F., Satz, P., Gaier, D. J., Ganzeil, S., Kharabi, F. Minor physical anomalies in schizophrenia. Schiz. Bull. 1989: 15, 91–99.Google Scholar
  30. 30.
    O’Callaghan, E., Larkin, C., Kinsella, A., Waddington, J. L. Familial, obstetric and other clinical correlates of minor physical anomalies in schizophrenia. Amer. J. Psychiat. 1991: 148, 479–483.PubMedGoogle Scholar
  31. 31.
    Kendler, K. S. The genetics of schizophrenia: an overview. In: Tsuang, M. T., Simpson, J. C. editors. Handbook of schizophrenia. Vol. 3. New York: Elsevier, 1988.Google Scholar
  32. 32.
    O’Callaghan, E., Larkin, C., Waddington, J. L. Obstetric complications in schizophrenia and the validity of maternal recall. Psychol. Med. 1990: 20, 89–94.PubMedGoogle Scholar
  33. 33.
    Omoy, A., Benady, S., Kohen-Raz, R. Association between maternal bleeding during gestation and congenital anomalies in the offspring. Amer. J. Obstet Gynecol. 1976: 124, 474–478.Google Scholar
  34. 34.
    Williams, M. A., Mittendorf, R., Lieberman, E., Monson, R. R. Adverse infant outcomes associated with first-trimester vaginal bleeding. Obstet. Gynecol. 1991: 78, 14–18.PubMedGoogle Scholar
  35. 35.
    Johnstone, E. C., Crow, T. J., Frith, C. D., Husband, J., Kreel, L. Cerebral ventricular size and cognitive impairment in schizophrenia. Lancet 1976: ii, 924–926.CrossRefGoogle Scholar
  36. 36.
    Lewis, S. W. Computerised tomography in schizophrenia 15 yean on. Brit. J. Psychiat. 1990: 157 (Suppl. 9), 16–24.Google Scholar
  37. 37.
    Waddington, J. L., O’Callaghan, E., Larkin, C., Redmond, O., Stack, J. Ennis, J. T. Magnetic resonance imaging and spectroscopy in schizophrenia. Brit. J. Psychiat. 1990: 157 (Suppl. 9), 56–65.Google Scholar
  38. 38.
    Suddath, R. L., Christison, G. W., Torrey, E. F., Casanova, M. F., Weinberger, D. R. Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia. N. Engl. J. Med. 1990: 322, 789–794.PubMedGoogle Scholar
  39. 39.
    Roberts, G. W. Schizophrenia: a neuropathological perspective. Brit. J. Psychiat. 1991: 158, 8–17.PubMedGoogle Scholar
  40. 40.
    Sponheim, S. R., Iacono, W. G., Beiser, M. Stability of ventricular size after the onset of psychosis in schizophrenia. Psychiat. Res: Neuroimaging 1991: 40, 21–29.Google Scholar
  41. 41.
    Bogerts, B., Ashtari, M., Degreef, G., Alvir, J. M., Bilder, R. M., Lieberman, J. A. Reduced temporal limbic structure volumes on magnetic resonance imaging in first episode schizophrenia. Psychiat. Res: Neuroimaging 1990: 35, 1–13.Google Scholar
  42. 42.
    DeLisi, L. E., Hoff, A. L., Schwartz, J. E., Shields, G. W., Halthore, S. N., Gupta, S. M., Herrn, F. A., Anand, A. K. Brain morphology in firstepisode schizophrenic-like psychotic patients: a quantitative magnetic resonance imaging study. Biol. Psychiat 1991: 29, 159–175.PubMedCrossRefGoogle Scholar
  43. 43.
    Waddington, J. L., O’Callaghan, E., Buckley, P., Larkin, C., Redmond, O., Suck, J., Ennis, J. T. The age-dependencies of MRI abnormalities in schizophrenia suggest early ventricular enlargement but later prominence of cortical atrophy. Schiz. Res. 1991: 5, 188–189.CrossRefGoogle Scholar
  44. 44.
    O’Callaghan, E., Buckley, P., Redmond, O., Stack, J., Ennis, J. T., Larkin, C., Waddington, J. L. Abnormalities of cerebral structure in schizophrenia on magnetic resonance imaging: interpretation in relation to the neurodevelopmental hypothesis. J. Roy. Soc. Med. (in press).Google Scholar
  45. 45.
    Flaum, M., Arndt, S., Andreasen, N. C. The role of gender in studies of ventricular enlargement in schizophrenia: a predominantly male effect. Amer. J. Psychiatry 1990: 147, 1327–1332.Google Scholar
  46. 46.
    Goldstein, J.M., Tsuang, M.T. Gender and schizophrenia. Schiz. Bull. 1990: 16, 179–183.Google Scholar
  47. 47.
    Schaefer, G. B., Schuman, R. M., Wilson, D. A., Saleeb, S., Domek, D. B., Johnson, S. F., Bodensteiner, J. B. Partial agenesis of the anterior corpus callosum: correlation between appearance, imaging and neuropathology. Pediat. Neurol. 1991: 7, 39–44.CrossRefPubMedGoogle Scholar
  48. 48.
    Bordarier, C., Robain, O., Ponsot, G. Bilateral porencephalic defect in a newborn after injection of benzol during pregnancy. Brain Develop. 1991: 13, 126–129.Google Scholar
  49. 49.
    Sato, Y., Kao, S. C. S., Smith, W. L. Radiographic manifestations of anomalies of the brain. Radiol. Clin. N. Amer. 1991: 29, 179–194.PubMedGoogle Scholar
  50. 50.
    Cannon, T. D., Mednick, S. A., Pamas, J. Genetic and perinatal determinants of structural brain deficits in schizophrenia. Arch Gen. Psychiat. 1988: 46, 883–889.Google Scholar
  51. 51.
    Waddington, J.L., O’Callaghan, E., Larkin, C. Premorbidneuropathology in schizophrenia, Lancet 1988: ii, 959–960.CrossRefGoogle Scholar
  52. 52.
    Mann, D. M. A., Royston, M. C., Ravindra, C. R. Some morphometric observations on the brains of patients with Down’s syndrome; their relationship to age and dementia. J. Neurol. Sci. 1990: 98, 153–164.CrossRefGoogle Scholar
  53. 53.
    Kendell, R. E., Adams, W., Unexplained fluctuations in the risk for schizophrenia by month and year of birth. Brit. J. Psychiat 1991: 158, 758–763.PubMedCrossRefGoogle Scholar
  54. 54.
    O’Callaghan, E., Redmond, O., Ennis, R., Suck, J., Kinsella, A., Ennis, J. T., Larkin, C., Waddington, J. L. Initial investigation of the left temporoparietal region in schizophrenia by31P magnetic resonance spectroscopy. Biol. Psychiat. 1991: 29, 1149–1152.PubMedCrossRefGoogle Scholar
  55. 55.
    Laxer, K. D., Hubesch, B., Sappey-Marinier, D., Weiner, M. W. Increased pH and inorganic phosphate in temporal seizure foci, demonstrated by 31P MRS. Epilepsia (in press).Google Scholar
  56. 56.
    Benes, M. Myelination of cortical-hippocampal relays during late adolescence. Schiz. Bull. 1989: 15, 585–593.Google Scholar
  57. 57.
    Hoffman, R. E., Dobscha, S. K. Cortical pruning and the development of schizophrenia: a computer model. Schiz. Bull. 1989: 15, 477–490.Google Scholar
  58. 58.
    Roberts, G. W., Done, D. J., Bruton, C., Crow, T. J. A “mock up” of schizophrenia: temporal lobe epilepsy and schizophrenia-like psychosis. Biol. Psychiat 1990: 28, 127–143.PubMedCrossRefGoogle Scholar

Copyright information

© Springer 1991

Authors and Affiliations

  • John L. Waddington
    • 1
  1. 1.Department of Clinical PharmacologyRoyal College of Surgeons in Ireland, St. Stephen’s GreenDublin 2

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