The inhibition of gastric acid secretion by gastric mucus

  • Ivan D. A. Johnston
  • D. W. Wilbur


Intravenous administration of an extract of gastric mucus inhibits the secretion of gastric acid.

Local irrigation of canine gastric pouches with Eugenol increases the secretion of gastric mucus, inhibits the histamine-stimulated secretion of acid, but has no effect on pepsin activity.

Acetylcholine has a similar but less marked effect.

Repeated applications of Eugenol do not interfere with acid production from gastric pouches.


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Copyright information

© Springer 1962

Authors and Affiliations

  • Ivan D. A. Johnston
    • 1
  • D. W. Wilbur
    • 2
  1. 1.Department of SurgeryQueen’s University of BelfastIreland
  2. 2.Mayo ClinicRochester

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