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Chinese Journal of Cancer Research

, Volume 3, Issue 3, pp 6–13 | Cite as

Observation on husbandry and reproduction of mice with severe combined immunodeficiency and histological examination of their immune organs

  • Wang Ge 
  • Chang Bo 
  • Li Yan 
  • Zhang Xiaojuan 
  • Xue Kexun 
  • Gao Jin 
  • Zhao Xuemei 
  • Gu Pei 
Basic Investigations
  • 21 Downloads

Abstract

Severe Combined Immunodeficiency (SCID) mice were maintained in a plastic film isolator in which specific-pathogen-free (SPF) condition was kept. Their average litter size was 3.4, non-productive rate 27.2%, and weaned-to-born ratio 73.5%. Thymus glands of SCID mice were found to consist of a rudimentary medulla without cortex, and to contain few lymphocytes. Spleen follicles were empty, virtually devoid of lymphocytes. Lymph nodes had no clear cortex, totally appeared to be empty with few lymphocytes. Lymphoid tissues in submucosa of intestines were undeveloped. Circulating lymphocytes only comprised a small fraction of total leukocytes of peripheral blood (10–24%). Possible uses of SCID mice were discussed.

Key words

SCID mice husbandry reproduction immune tissue 

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Copyright information

© Chinese Journal Of Cancer Research 1991

Authors and Affiliations

  • Wang Ge 
    • 1
  • Chang Bo 
    • 1
  • Li Yan 
    • 1
  • Zhang Xiaojuan 
    • 1
  • Xue Kexun 
    • 2
  • Gao Jin 
    • 2
  • Zhao Xuemei 
    • 2
  • Gu Pei 
    • 2
  1. 1.Institute of Laboratory Animal ScienceChinese Academy of Medical SciencesBeijing
  2. 2.Institute of Basic Medical SciencesChinese Academy of Medical SciencesBeijing

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