Abstract
132 gastric carcinomas were examined immunohistochemically with McAb to p53 protein in order to investigate the relationship between the expression of p53 protein and histological differentiation of gastric carcinoma, and to approach the mechanism of infiltration and metastasis of gastric carcinoma. The results showed that nuclear expression of p53 protein was significantly related to tumor size, depth of invasion, lymph node and liver metastases; but not related to histological differentiation. It is suggested that the accumulation of p53 protein was increased with the progression of gastric carcinoma, and therefore the cancer clone with p53 gene mutation may play an important role in the development of tumor invasion and metastasis.
Similar content being viewed by others
References
Iggo R, et al. Increased expression of mutant forms of p53 oncogen nin primary lung cancer. Lancet 1990; 335: 675.
Verly JM, et al. Loss of chromosomes 17p13 sequences and mutation of p53 in human carcinomas. Oncogene 1991; 6: 413.
Batek J, et al. Genetic and immunohistochemical analysis of mutant p53 in human breast cancer cell lines. Oncogene 1990; 5: 893.
Martin HM, et al. p53 expression and prognosis in gastric carcinoma. Int J Cancer 1992; 50: 859.
Seruca R, et al. p53 mutatijons in gastric carcinomas. Br J Cancer 1992; 65: 708.
Norton AJ, et al. Brief high-temperature heat denaturation (Pressure Cooking): A simple and effective method of antigen retrival for routinely tissues. J Pathol 1994; 173: 371.
Sidranskey D, et al. Identifications of p53 mutations in bladder cancer and urine samples. science 1991; 152: 706.
Joypaul BV, et al. Enzyme-linked immunosorbent assay for p53 in gastrointestinal malignancy: comparison with immunohistochemistry. Histopathol 1993; 23: 465.
Midgley CA, et al. Analysis of p53 expression in human tumors: an antibody ransed against human p53 expressed in E.coli. Cell Sci 1992; 101: 183.
Craven JL, et al. Radical surgery for gastric cancer. In: Preece PE, et al. eds. Cancer of the stomach. London: Grune and stratton. 1986; 165–188.
Adeshek K, et al. Cancer of the stomach. Review of consecutive ten-year intervals. Ann Surg 1979; 186: 6.
Meyer HJ, et al. Patterns of recurrence in relation to the rapeutic strategy in gastric cancer. Scand J Gastroenterol 1987; 22 (Suppl 133): 45.
Rohde H, et al. What causes in-hospital mortality of surgical patients with cancer of the stomach? Scand J Gastroenterol 1987; 22 (Suppl 133): 76.
Remine WH, et al. Long-term survival (10 to 56 years) after surgery for carcinoma of the stomach. Am J Surg 1969; 117: 177.
Korenaga D, et al. Long-term survival in Japanese patients with far advanced carcinoma of the stomach. World J Surg 1988; 12: 236.
Zhang YC, et al. Precancerous conditions and lesions of the stomach. Springer-Verlag, Heideberg 1993; 1.
Hall PA, et al. High levels of p53 protein in UV-irradiated normal human skin. Oncogen 1993; 8L 203.
Author information
Authors and Affiliations
Additional information
This project was supported by the National Natural Sciences Foundation of China.
Rights and permissions
About this article
Cite this article
Xin, Y., Zhao, F., Wu, D. et al. Relationship between the mutation of P53 gene and infiltration, metastasis and prognosis of gastric carcinoma. Chinese Journal of Cancer Research 8, 263–266 (1996). https://doi.org/10.1007/BF02954745
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02954745