Chinese Journal of Cancer Research

, Volume 8, Issue 4, pp 263–266 | Cite as

Relationship between the mutation of P53 gene and infiltration, metastasis and prognosis of gastric carcinoma

  • Xin Yan 
  • Zhao Fengkai 
  • Wu Dongying 
  • Wang Yanping 
  • Xu Lei 
  • Zhang Yinchang 
  • Kristin Henry
Clinical Observations


132 gastric carcinomas were examined immunohistochemically with McAb to p53 protein in order to investigate the relationship between the expression of p53 protein and histological differentiation of gastric carcinoma, and to approach the mechanism of infiltration and metastasis of gastric carcinoma. The results showed that nuclear expression of p53 protein was significantly related to tumor size, depth of invasion, lymph node and liver metastases; but not related to histological differentiation. It is suggested that the accumulation of p53 protein was increased with the progression of gastric carcinoma, and therefore the cancer clone with p53 gene mutation may play an important role in the development of tumor invasion and metastasis.

Key words

p53 gene Tumor suppresser gene Metastasis Gastric carcinoma 


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Copyright information

© Chinese Journal Of Cancer Research 1996

Authors and Affiliations

  • Xin Yan 
    • 1
  • Zhao Fengkai 
    • 1
  • Wu Dongying 
    • 1
  • Wang Yanping 
    • 1
  • Xu Lei 
    • 1
  • Zhang Yinchang 
    • 1
  • Kristin Henry
    • 2
  1. 1.Cancer InstituteChina Medical UniversityShenyang
  2. 2.Department of Histopathology, Charring Cross & Westminster Medical SchoolUniversity of LondonUK

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