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The early relative biological effectiveness of single dose of fast neutrons (35 MeVp→Be) for bone marrow in mice

  • Sun Yan 
  • Han Shukui 
  • Xu Bo 
  • Zhang Shuhui 
  • Tang Jinghua 
  • Chang Weike 
  • Shen Wenjiang 
Clinical Observations

Abstract

The early RBE of the bone marrow in mice after single irradiation with fast neutrons (35 MeVp→Be) was studied.60Co-γ ray was used for referent beams. Using the dose making 50% loss of the nucleated cells of bone marrow in mice relative to control group mice to calculated the RBE value which was 2.13±0.18. Meanwhile, the relationship of the RBE values and the dose of neutrons was noted. On log-log plot, the RBE values decrease with increasing dose of fast neutrons and it is consistent with a slope of −0.39±0.10. The α/β ratios were estimated from linear-quadratic model of cell survival, they are 14.4±1.30 Gy for fast neutrons and 0.83±0.10 Gy for γ-ray, respectively.

Key words

Fast neutrons Relative biological effectiveness Bone marrow Early reaction 

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Copyright information

© Chinese Journal Of Cancer Research 1995

Authors and Affiliations

  • Sun Yan 
    • 1
  • Han Shukui 
    • 1
  • Xu Bo 
    • 1
  • Zhang Shuhui 
    • 1
  • Tang Jinghua 
    • 1
  • Chang Weike 
    • 1
    • 2
  • Shen Wenjiang 
    • 1
  1. 1.Department of RadiotherapyBeijing Institute for Cancer ResearchBeijing
  2. 2.Institute of High Energy PhysicsAcademia SinicaBeijing

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