Summary
Five patients with chronic renal failure on haemodialysis with the normochromic normocytic anaemia of chronic renal failure, were treated with Desferrioxamine 40 mgs/Kg/week, over a period of three months for aluminium osteodystrophy. The mean haemoglobin rise was 2.5±0.3 grams% (P< 0.05). The haematocrit rose by 9±2.5% (P< 0.05). The mean ±s.e.m. M.C.V. rise was 5±0.85 Fl (P< 0.001) and the mean ±s.e.m. M.C.H. rise was 2.5±0.28 (P< 0.001). The red blood cell and M.C.H.C. did not show a significant rise. Serum Ferritin levels were raised with a mean of 1500±350 and fell by 500±150 (P< 0.001). The transfusion requirement of the five patients (previously 10 units per month) fell to 2 units per month over the same period. The renal indices did not show a significant change.
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Elliott, H. L., Dryburgh, F., Fell, G. S. et al. Aluminium toxicity during regular haemodialysis. Br. Med. J. 1978: 1101–1103.
O’Hare, J. A., Murnaghan, D. J. Reversal of aluminium-induced haemodialysis anaemia by low-aluminium dialysate. N. Engl. J. Med. 1982: 306, 654–656.
Kaiser, L., Schwartz, K. A., Burnatowska Hledin, M. A. et al. Microcytic anaemia secondary to intraperitoneal aluminium in normal and uraemic rats. Kidney Int. 1986: 26, 269–274.
Meredith, P. A., Moore, M. R., Goldbert, A. The effects of aluminium, lead and zinc on delta-amino laevulinic acid dehydratase. Biochem. Soc. Trans. 1974: 1243–1245.
Praga, M., Andres, A., Nieto, J. et al. Desferrioxamine (DFO) improves the anaemia of haemodialysis patients without aluminium (AL) intoxication. Proc. EDTA 1986: 23, 64 (abstract).
Tielemans, C., Collart, F., Wens, R. et al. Improvement of anaemia with deferoxamine in haemodialysis patients with aluminium-induced bone disease. Clin. Nephrol. 1985: 24, 237–241.
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O’Brien, A.A.J., Moore, D.P. & Keogh, J.A.B. The response of the normochromic normocytic anaemia of chronic renal failure to Desferrioxamine. I.J.M.S. 156, 236–237 (1987). https://doi.org/10.1007/BF02954052
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DOI: https://doi.org/10.1007/BF02954052