The response of the normochromic normocytic anaemia of chronic renal failure to Desferrioxamine
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Five patients with chronic renal failure on haemodialysis with the normochromic normocytic anaemia of chronic renal failure, were treated with Desferrioxamine 40 mgs/Kg/week, over a period of three months for aluminium osteodystrophy. The mean haemoglobin rise was 2.5±0.3 grams% (P< 0.05). The haematocrit rose by 9±2.5% (P< 0.05). The mean ±s.e.m. M.C.V. rise was 5±0.85 Fl (P< 0.001) and the mean ±s.e.m. M.C.H. rise was 2.5±0.28 (P< 0.001). The red blood cell and M.C.H.C. did not show a significant rise. Serum Ferritin levels were raised with a mean of 1500±350 and fell by 500±150 (P< 0.001). The transfusion requirement of the five patients (previously 10 units per month) fell to 2 units per month over the same period. The renal indices did not show a significant change.
KeywordsChronic Renal Failure Transfusion Requirement Serum Ferritin Level Desferrioxamine Haematological Index
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