Skip to main content
SpringerLink
Log in

Pulsatile LHRH therapy for induction of ovulation in patients with hyperprolactinaemia and bromocriptine intolerance

  • Published:
Irish Journal of Medical Science Aims and scope Submit manuscript

Summary

Intravenous pulsatile luteinizing hormone releasing hormone (LHRH) therapy was administered to four patients with hyperprolactinaemia and anovulation, all of whom were unable to tolerate bromocriptine. During six cycles of treatment the response was evaluated by serial measurements of serum luteinizing hormone (LH), follicle stimulating hormone (FSH), oestradiol, progesterone and prolactin, and ovarian ultrasonography. Four of the five completed cycles were ovulatory, one with an inadequate luteal phase and one cycle was anovulatory. During a thir cycle of treatment one patient developed a symptomatic ovarian cyst. Restoration of normal LH pulses using pulsatile LHRH therapy restores ovulation in the majority of patients with hyperprolactinaemia. Its safety and effectiveness as a means of restoring fertility in hyperprolactinaemic patients intolerant of bromocriptine should be determined.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Caro, J. F., Woolf, P. D. Pituitary-ovarian axis responsitivity to prolonged Gn-Rh infusion in normal hyperprolactinaemic women. J. Clin. Endocrinol. Metab. 1980: 50, 999–1004.

    PubMed  CAS  Google Scholar 

  2. Moult, P. J., Rees, L. J., Besser, G. M. Pulsatile gonadotrophin secretion in hyperprolactinaemic amenorrhoea and the response to bromocriptine therapy. Clin. Endocrinol. 1982: 16, 153–162.

    Article  CAS  Google Scholar 

  3. Sauder, S. E., Frager, M., Case, E. D., Ketch, R. P., Marshall, J. C. Abnormal patterns of pulsatile luteinizing hormone secretion in women with hyperprolactinaemia and amenorrhoea: responses to bromocriptine. J. Clin. Endocrinol. Metab. 1984: 59, 941–948.

    Article  PubMed  CAS  Google Scholar 

  4. Leyendecker, G., Struve, T., Plotz, E. J. Induction of ovulation with chronic intermittent (pulsatile) administration of LHRH in women with hypothalamic and hyperprolactinaemic amenorrhoea. Arch. Gynecol. 1980: 229, 177–190.

    Article  PubMed  CAS  Google Scholar 

  5. Wilson, J. M., Traub, A. I., Sheridan, B., Atkinson, A. B., Thompson, W. Conventional dose intravenous pulsatile LHRH therapy does not induce ovulation in polycystic disease. (Submitted for publication).

  6. Bohnet, H. G., Dahien, H. G., Wuttke, W., Schneider, H. P. G. Hyperprolactinaemic anovulatory syndrome. J. Clin. Endocrinol. Metab. 1975: 42, 132–143.

    Google Scholar 

  7. Klibanski, A., Beitins, I. Z., Zervas, N. T., McArthur, J. W., Ridway, E. C. Subunit and gonadotrophin responses to luteinizing hormone-releasing hormone in hyperprolactinaemic women before and after bromocriptine. J. Clin. Endocrinol. Metab. 1983: 56, 774–780.

    PubMed  CAS  Google Scholar 

  8. Araki, S., Chikazawa, K., Ohkusa, T.et al. Follicular development and a single ovulation induced with pulsatile administration of Gn-Rh in anovulatory women: studies of hormonal analysis and follicular sonometry. Endocrinol. Jpn. 1983: 30, 753–762.

    PubMed  CAS  Google Scholar 

  9. Mason, P., Adams, J., Morris, D. V.et al. Induction,of ovulation with pulsatile LH-RH. Br. Med. J. 1984: 288, 181–185.

    CAS  Google Scholar 

  10. Bouchad, P., Largoguey, M., Braitly, S., Schaison, G. Gonadotrophin-releasing hormone pulsatile administration restores luteinizing hormone pulsatility and normal testosterone levels in males with hyperprolactinaemia. J. Clin. Endocrinol. Metab. 1985: 60, 258–262.

    Google Scholar 

  11. Menon, V., Butt, W. R., Clayton, R. N., Logan Edwards, R., Lynch, S. S. Pulsatile administration of GnRH for the treatment of hypogonadotrophic hypogonadism. Clin. Endocrinol. 1984: 21, 223–232.

    Article  CAS  Google Scholar 

  12. McNatty, K. P., Sawers, R. S., McNeilly, A.S.A possibte role for prolactin inc control of steroid secretion by the human graafian follicle Nature 1974. 250, 653–655.

    Article  PubMed  CAS  Google Scholar 

  13. Franchimont, P., Dourcy, C., Legros, J. J.et al. Prolactin levels during the menstrual cycle. Clin. Endoerinol. 1976: 5, 643–650.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Royal Maternity Hospital, Sir George E. Clark Metabolic Unit, and Regional Endocrine Laboratory, Royal Victoria Hospital, BT12 6BA, Belfast, Northern Ireland

    Janet M. Wilson, A. B. Atkinson, B. Sheridan, A. I. Traub & J. M. G. Harley

Authors
  1. Janet M. Wilson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. B. Atkinson
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. B. Sheridan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. I. Traub
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J. M. G. Harley
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wilson, J.M., Atkinson, A.B., Sheridan, B. et al. Pulsatile LHRH therapy for induction of ovulation in patients with hyperprolactinaemia and bromocriptine intolerance. I.J.M.S. 156, 232–235 (1987). https://doi.org/10.1007/BF02954051

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02954051

Keywords

Search

Navigation