Pulsatile LHRH therapy for induction of ovulation in patients with hyperprolactinaemia and bromocriptine intolerance
Intravenous pulsatile luteinizing hormone releasing hormone (LHRH) therapy was administered to four patients with hyperprolactinaemia and anovulation, all of whom were unable to tolerate bromocriptine. During six cycles of treatment the response was evaluated by serial measurements of serum luteinizing hormone (LH), follicle stimulating hormone (FSH), oestradiol, progesterone and prolactin, and ovarian ultrasonography. Four of the five completed cycles were ovulatory, one with an inadequate luteal phase and one cycle was anovulatory. During a thir cycle of treatment one patient developed a symptomatic ovarian cyst. Restoration of normal LH pulses using pulsatile LHRH therapy restores ovulation in the majority of patients with hyperprolactinaemia. Its safety and effectiveness as a means of restoring fertility in hyperprolactinaemic patients intolerant of bromocriptine should be determined.
KeywordsProlactin Follicle Stimulate Hormone Bromocriptine Prolactin Level Royal Victoria Hospital
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