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A molecular epidemiologic marker of hepatocellular carcinoma from aflatoxin B1 contaminated area in the Southwest of Guangxi

  • Basic Investigations
  • Published:
Chinese Journal of Cancer Research

Abstract

HCC specimens from high and low AFB1 risk areas in Guangxi showed different frequency of p53 mutational hot-spot, which were 20/35 (57%) and 1/10 by DNA sequencing and 36/52 (69%) and 2/10 by RFLP analysis respectively. Their differences were significant (P<0.01). Mutational points of p53 gene induced by AFB1 mutagen almost exclusively clustered at codon 249 third nucleotide and by the form of G to T transversion only. We call it “AFB1 mutational hot-spot”. It turns out to be a significant marker for molecular epidemio-logic survey to decide how many HCC and which individuals are induced by AFB1 mutagen, and if emergence of this marker in HCC is frequent in certain region it indicated that there is heavy contamination by AFB1.

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Authors and Affiliations

  1. University College London Medical School, WC1E 6JJ, London

    Pan Langxing & Peng Huaizheng

  2. Guangxi Medical University, 530021, Nanning

    Deng Zhuolin & Ma Yun

Authors
  1. Deng Zhuolin
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  2. Ma Yun
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  3. Pan Langxing
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  4. Peng Huaizheng
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Deng, Z., Ma, Y., Pan, L. et al. A molecular epidemiologic marker of hepatocellular carcinoma from aflatoxin B1 contaminated area in the Southwest of Guangxi. Chinese Journal of Cancer Research 9, 167–169 (1997). https://doi.org/10.1007/BF02953872

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  • DOI: https://doi.org/10.1007/BF02953872

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