Advertisement

The life of the red blood cell

  • L. J. Witts
Article
  • 11 Downloads

Conclusion

It may well be that the main value of these studies will be to focus interest on the remarkable properties of the red cell and to stimulate yet more work on its ultramicroscopic structure and biochemical properties. As more immediate gains, they have given us improved methods of blood storage, better diagnosis of the hæmolytic anæmias and more understanding of the mechanism of diseases such as polycythæmia vera. For the clinical scientist they have opened up new lines of work within the competence of those of us whose task it is to study the organism as a whole. The volume of accurate metabolic work on diseases of the blood is small. This is not from lack of requirement, for we know little about the mechanism and treatment of the common forms of anæmia from trauma, infection and malnutrition. It has rather been because of the formidable nature of the task, the difficulties imposed by the facts that much of the metabolism, as for example that of iron, goes on in a closed circle and that the level of the blood is affected by the two variables of production and destruction. Now that we can measure the rates of blood formation and blood destruction independently, with reasonable accuracy and simplicity, I think we may well see a recrudescence of interest in the metabolic problems of anæmia and blood regeneration, and one may hope that it will be as fruitful as the application of quantitative methods has proved in other fields of metabolism.

References

  1. Ashby, W. (1919).J. exp. Med., 29, 267.PubMedCentralPubMedCrossRefGoogle Scholar
  2. Baar, H. S., and Lloyd, T. W. (1943).Arch. Dis. Childh., 18, 1.PubMedCentralPubMedCrossRefGoogle Scholar
  3. Bale, Yuile, De La Vergne, Miller, and Whipple. (1949).J. exp. Med., 90, 315.PubMedCentralPubMedCrossRefGoogle Scholar
  4. Brown, Hayward, Powell, and Witts. (1944).J. Path. Bact., 56, 81.CrossRefGoogle Scholar
  5. Bushby, Kekwick, Marriott, and Whitby. (1940).Brit. Med. J., 2, 414.CrossRefGoogle Scholar
  6. Callender, Nickel, Moore, and Powell. (1949).J. lab. clin. Med., 34, 90.PubMedGoogle Scholar
  7. Callender, S. T., Powell, E. O., and Witts, L. J. (1945).J. Path. Bact., 57, 129.CrossRefGoogle Scholar
  8. —— (1947). Ibid., 59, 519.PubMedCrossRefGoogle Scholar
  9. Dacie, J. V., and Mollison, P. L. (1943).Lancet, i, 550.CrossRefGoogle Scholar
  10. Finch, Wolff, Rath, and Fluharty. (1949).J. lab. clin. Med., 34, 1480.Google Scholar
  11. Foy, Kondi, Rebelo, and Sociro. (1945).Tr. Roy. Soc. trop. Med. & Hyg., 38, 271.CrossRefGoogle Scholar
  12. Freeman, J. (1947).Brit. Med. J., i, 659.Google Scholar
  13. Gibson, Evans, Aub, Sack, and Peacock. (1947).J. clin. Invest., 26, 715.PubMedCentralCrossRefGoogle Scholar
  14. Hawkins, W. B., and Whipple, G. H. (1938).Amer. J. Physiol., 122, 418.Google Scholar
  15. Huff, R., Hennessey, T., and Lawrence, J. H. (1949).J. clin. Invest., 28, 790.Google Scholar
  16. Jope, E. M. (1946).Brit. J. indust. Med., 3, 136.Google Scholar
  17. Josephs, H. W. (1950).Bull. Johns Hopkins Hosp., 86, 1.PubMedGoogle Scholar
  18. Kirkegaard, A., and Larsen, K. (1942).Acta med. Scand., 110, 510.CrossRefGoogle Scholar
  19. Larsen, K. (1950).Personal communication.Google Scholar
  20. Lawrence, J. S., and Valentine, W. N. (1947).Blood, 2, 40.PubMedGoogle Scholar
  21. Lloyd, T. W. (1940).On the Aetiology of Acholuric Family Jaundice. M.D. Thesis, Birmingham, England.Google Scholar
  22. Loutit, J. F. (1946).Proc. Roy. Soc. Med., 39, 757.PubMedGoogle Scholar
  23. Maizels, M., and Paterson, J. H. (1940).Brit. Med. J., ii, 417.Google Scholar
  24. Mills, J. N. (1946).J. Physiol, 105, 16p.Google Scholar
  25. Mogensen, E. (1938).Studies on the Size of the Red Blood Cells. Copenhagen and London.Google Scholar
  26. Mollison, P. L. (1943).Arch. Dis. Childh., 18, 161.PubMedCentralPubMedCrossRefGoogle Scholar
  27. Pauling, L., Itano, H. A., Singer, S. J., and Wells, I. C. (1949).Science, 110, 543.PubMedCrossRefGoogle Scholar
  28. Ponder, E.Hœmolysis and Related Phenomena. London, 1948.Google Scholar
  29. Schiodt, E. (1938).Acta med. Scand., 95, 49.CrossRefGoogle Scholar
  30. Shemin, D., and Rittenberg, D. (1946).J. biol. Chem., 166, 621 and 627.PubMedGoogle Scholar
  31. Stewart, W. B., Stewart, J. M., Izzo, M. J., and Young, L. E. (1950).J. exp. Med., 91, 147.PubMedCentralPubMedCrossRefGoogle Scholar
  32. Stewart, Witts, Higgins, and O’Brien. (1945).Brit. J. indust. Med., 2, 74.Google Scholar
  33. Thompson, D’Arcy, W. (1942).On Growth and Form, Cambridge,Google Scholar
  34. Witts, L. J. (1932).Lancet, i, 495.CrossRefGoogle Scholar
  35. Young, L. E., and Lawrence, J. S. (1945).J. clin. Invest., 24, 554.PubMedCentralPubMedCrossRefGoogle Scholar

Copyright information

© Springer 1950

Authors and Affiliations

  • L. J. Witts

There are no affiliations available

Personalised recommendations