The occurrence and possible significance of cryo-globulinaemia in multiple myelomatosis

Summary

A case is described in which cryoglobulinaemia occurred in multiple myelomatosis. The diagnosis was suggested when carrying out a routine E.S.R. by a failure of the red blood cells to sediment in the absence of clots at room temperature. Electrophoretic studies showed a marked increase in gramma flobulins. The possibility of a poor antibody response was noted in view of recurrent respiratory and other infections.