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Irish Journal of Medical Science

, Volume 147, Supplement 1, pp 53–56 | Cite as

Social isolation in the young rat: Neurochemical correlates of chronic amphetamine treatment

  • Alun Morinan
Article

Summary

The neurochemical changes induced by chronic treatment with d-amphetamine in rats housed individually or in groups of 4 has been assessed. Alteration in GABA (midbrain and amygdala), DA (midbrain) and NA (striatum and amygdala) concentrations were independent of environmental treatment. Changes in 5-HT (amygdala), DA (hippocampus and amygdala) and NA (midbrain and hippocampus) were dependent on the housing condition. These findings attest to the diverse influence of amphetamine on brain biogenic amines, but more importantly, that modification of the environment can alter the effect of this drug on these systems.

Keywords

Amphetamine Biogenic Amine Neurochemical Change Dexamphetamine Diverse Influence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 1978

Authors and Affiliations

  • Alun Morinan
    • 1
  1. 1.Department of PharmacologyUniversity CollegeGalway

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