Social isolation in the young rat: Neurochemical correlates of chronic amphetamine treatment
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The neurochemical changes induced by chronic treatment with d-amphetamine in rats housed individually or in groups of 4 has been assessed. Alteration in GABA (midbrain and amygdala), DA (midbrain) and NA (striatum and amygdala) concentrations were independent of environmental treatment. Changes in 5-HT (amygdala), DA (hippocampus and amygdala) and NA (midbrain and hippocampus) were dependent on the housing condition. These findings attest to the diverse influence of amphetamine on brain biogenic amines, but more importantly, that modification of the environment can alter the effect of this drug on these systems.
KeywordsAmphetamine Biogenic Amine Neurochemical Change Dexamphetamine Diverse Influence
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