Irish Journal of Medical Science

, Volume 147, Supplement 1, pp 53–56 | Cite as

Social isolation in the young rat: Neurochemical correlates of chronic amphetamine treatment

  • Alun Morinan


The neurochemical changes induced by chronic treatment with d-amphetamine in rats housed individually or in groups of 4 has been assessed. Alteration in GABA (midbrain and amygdala), DA (midbrain) and NA (striatum and amygdala) concentrations were independent of environmental treatment. Changes in 5-HT (amygdala), DA (hippocampus and amygdala) and NA (midbrain and hippocampus) were dependent on the housing condition. These findings attest to the diverse influence of amphetamine on brain biogenic amines, but more importantly, that modification of the environment can alter the effect of this drug on these systems.


Amphetamine Biogenic Amine Neurochemical Change Dexamphetamine Diverse Influence 
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  1. Hatch, A. M., Wiberg, G. S., Zawidzka, Z., Cann, M., Airth, J. M. and Grice, H. C. 1965. Isolation Syndrome in the rat. Toxic. Appl. Pharmac. 7, 737.CrossRefGoogle Scholar
  2. Hays, W. L. 1973. Statistics for the Social Sciences. New York. Holt, Rinehart and Winston, p. 494.Google Scholar
  3. Leonard, B. E., Neuhoff, V. and Tonge, S. R. 1975. The effect of the chronic administration of d-amphetamine upon circadian changes in amino acids in the pineal and pituitary glands of the rat. J. Neurosci. Res. 1, 83.PubMedCrossRefGoogle Scholar
  4. Leonard, B. E. and Tonge, S. R. 1969. The effect of some hallucinogenic drugs upon the metabolism of noradrenaline. Life Sci. 8, 815.PubMedCrossRefGoogle Scholar
  5. Lynch, M. A. 1976. An investigation of the mechanism of action of d-amphetamine on the metabolism of biogenic amines in discrete regions of the rat brain. M.Sc. Thesis, National University of Ireland.Google Scholar
  6. Morinan, A. and Leonard, B. E. 1976. The effects of social isolation in the young rat on concentrations of some neurotransmitters in the brain. Ir. J. Med. Sci. 145, 310.Google Scholar
  7. Randrup, A. and Munkvad, I. 1974. Pharmacology and physiology of stereotyped behaviour. J. Psychiat. Res. 11, 1.PubMedCrossRefGoogle Scholar
  8. Sahakian, B. J., Robbins, T. W., Morgan, M. J. and Iversen, S. D. 1975. The effects of psychomotor stimulants on stereotypy and locomotor activity in socially-deprived and control rats. Brain Res. 84, 195.PubMedCrossRefGoogle Scholar
  9. Synder, S. H., Axelrod, J. and Zweig, H. 1965. A sensitive and specific fluorescence assay for tissue serotonin. Biochem. Pharmac. 14, 831.CrossRefGoogle Scholar
  10. Uchida, T and O’Brien, R. D. 1964. The effects of hydrazine on rat brain 5-hydroxytryptamine, norepinephrine and λ-aminabutyric acid. Biochem. Pharmac. 13, 725.CrossRefGoogle Scholar
  11. Valzelli, L. 1973. The “Isolation Syndrome” in mice. Psychopharmacologia 31, 305.PubMedCrossRefGoogle Scholar
  12. Weinstock, M., Speiser, Z. and Ashkenazi, R. 1978. Changes in brain catecholamine turnover and receptor sensitivity induced by social deprivation in rats. Psychopharmacology. 56, 205.PubMedCrossRefGoogle Scholar

Copyright information

© Springer 1978

Authors and Affiliations

  • Alun Morinan
    • 1
  1. 1.Department of PharmacologyUniversity CollegeGalway

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