Effect of xiongshao capsule on vascular remodeling in porcine coronary balloon injury model
- 23 Downloads
Objective: To study the effect of Xiongshao capsule (XSC) on vascular remodeling in porcine coronary balloon injury model.Methods: Coronary artery restenosis model was established by oversized balloon injury at mid-region of the left anterior descending coronary artery. They were divided into 5 groups, untreated or treated with probucol, Xueguantong, low and high dose of XSC respectively, and compared. The effect of XSC on late lumen loss resulted from vascular remodeling was evaluated by quantitative histological method with combining histopathological analysis and coronary angiographie examination.Results: The (59 ± 20)% of late lumen loss was caused by vascular remodeling and (41 ± 20)% caused by intimai hyperplasia. Compared with the control group, all the treatment could significantly reduce the late lumen loss after balloon injury (P<0.05 orP < 0.01 ), both low and high dose of XSC could significantly reduce the late lumen loss caused by remodeling (P<0.05 and P<0.01 respectively).Conclusion: Vascular remodeling plays an important role in late lumen stenosis formation in coronary artery after balloon injury. XSC could significantly inhibit the pathological vascular remodeling, and thus reduce the late lumen loss and prevent the restenosis of the injured coronary artery.
Key WordsXiongshao capsule angioplasty restenosis vascular remodeling
Unable to display preview. Download preview PDF.
- 2.Shi DZ, Xu FQ, Li LZ. The experimental study of Xueguantong on preventing restenosis after percutaneous transluminal angioplasty. CJIM(Eng)1995; 1(4): 284–287.Google Scholar
- 3.Shi DZ, Li J, Ma XC. Clinical observation on preventing restenosis after PTCA treated with Concentrated Xuefu Zhuyu Pill. J Traditional Chin Med 1997;38:27–29.Google Scholar
- 7.Kovach JA, Mintz GS, Kent KM, et al. Serial intravascular ultrasound studies indicate that chronic recoil is an important mechanism of restenosis following transcatheter therapy [abstract]. J Am Coll Cardiol 1993;21(suppl A): 484A.Google Scholar
- 8.Mintz GS, Kovach JA, Saturmino PJ, et al. Geometric remodeling is the predominant mechanisms of late lumen loss after coronary angioplasty [abstract]. Circulation 1993; 88:(suppl I): 1–654.Google Scholar