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Effect of xiongshao capsule on vascular remodeling in porcine coronary balloon injury model

  • Hao Xu
  • Dazhuo Shi
  • Keji Chen
  • Xiaochang Ma
  • Yongli Li
  • Liang Meng
  • Weimin Yuan
Experimental Research
  • 23 Downloads

Abstract

Objective: To study the effect of Xiongshao capsule (XSC) on vascular remodeling in porcine coronary balloon injury model.Methods: Coronary artery restenosis model was established by oversized balloon injury at mid-region of the left anterior descending coronary artery. They were divided into 5 groups, untreated or treated with probucol, Xueguantong, low and high dose of XSC respectively, and compared. The effect of XSC on late lumen loss resulted from vascular remodeling was evaluated by quantitative histological method with combining histopathological analysis and coronary angiographie examination.Results: The (59 ± 20)% of late lumen loss was caused by vascular remodeling and (41 ± 20)% caused by intimai hyperplasia. Compared with the control group, all the treatment could significantly reduce the late lumen loss after balloon injury (P<0.05 orP < 0.01 ), both low and high dose of XSC could significantly reduce the late lumen loss caused by remodeling (P<0.05 and P<0.01 respectively).Conclusion: Vascular remodeling plays an important role in late lumen stenosis formation in coronary artery after balloon injury. XSC could significantly inhibit the pathological vascular remodeling, and thus reduce the late lumen loss and prevent the restenosis of the injured coronary artery.

Key Words

Xiongshao capsule angioplasty restenosis vascular remodeling 

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Copyright information

© The Chinese Journal of Integrated Traditional and Western Medicine Press 2000

Authors and Affiliations

  • Hao Xu
    • 1
  • Dazhuo Shi
    • 1
  • Keji Chen
    • 1
  • Xiaochang Ma
    • 1
  • Yongli Li
    • 2
  • Liang Meng
    • 2
  • Weimin Yuan
    • 2
  1. 1.Division of Cardiovascular Diseases, Xiyuan HospitalChina Academy of TCMBeijing
  2. 2.Department of Experimental Surgery, Fuwai Cardiovascular HospitalChinese Academy of Medical SciencesChina

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