Mycotoxin Research

, Volume 20, Issue 1, pp 42–48 | Cite as

Effect of deoxynivalenol (DON) on growing pigs and its modification by modified yeast cell wall or modified yeast cell wall and bentonite

  • S. Shehata
  • W. Richter
  • M. Schuster
  • H. Lindermayer


The study examined effect of two adsorbents on the toxicity of Deoxynivalenol (DON) in growing pigs in a feeding trial. 24 male growing pigs (average initial body weight 11.5 kg) were assigned to one of six dietary treatments: control (uncontaminated diet); control + 0.5% adsorbent I; DON contaminated diet (1.73 mg/kg); DON contaminated diet + 0.5% adsorbent I; control + 0.5% adsorbent II and DON contaminated diet + 0.5% adsorbent II. Two digestibility trials were conducted on the second and fourth week of the feeding period with a sampling period of 7 days to determine the digestibility of the nutrients and the amounts of DON in faeces and urine. At the end of the experiments, the pigs were slaughtered, followed by blood haematology and biochemi analys. These data suggest that the addition of 0.5% modified yeast cell wall or a combination of modified yeast cell wall and bentonite to the naturally DON — contaminated diets reduce the effect of DON on the immune system of pigs but do not play an significant role in detoxification of DON in growing pigs.


mycotoxins deoxynivalenol adsorbent feed growing pigs 


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  1. 1.
    VDLUFA Methodenbuch (1976): 4. Ergänzungslieferung 1999, VDLUFA Verlag Bonn, DeutschlandGoogle Scholar
  2. 2.
    Bergsjo, B., Langseth, W., Nafstad, I., Jansen, J.H. and Larsen, H.J.S. (1993): The effect of naturally deoxynivalenol — contaminated oats on the clinical condition, blood parameters, performance and carcass composition of growing pigs. Vet. Res.Communications,17 : 283 - 294CrossRefGoogle Scholar
  3. 3.
    Devegowda, G., Raju, M.V.L.N., Afzali, N., and Swamy, H.V.L.N. (1998): Mycotoxins, picture worldwide: Novel solutions for their counteraction. In T.P. Lyons and K.A. Jacques (Eds.) Biotechnology in the feed industry. Proc. of Alltech“s 14 the Annual symposium, Nottingham, U.K., 241 - 255Google Scholar
  4. 4.
    Döll, S., Dänicke, S., Valenta, H. and Flachowsky, G. (2001): In vitro studies on the evaluation of mycotoxin decontamination agents. Proceeding 23 Mykotoxin Workshop, 28 – 30 Mai, Vienna, Mycotoxin Research, 17A, 2, 214–218Google Scholar
  5. 5.
    Friend, D.W., Trenholm, H.L., Thompson, B.K., Prelusky, D.B. and Hartin, K.E. (1986): Effect of deoxynivalenol (DON) — contaminated diet fed to growing — finishing pigs on their performance at market weight, nitrogen retention and DON excretion. Can. J. Anim. Sci. 66 : 1075 - 1085Google Scholar
  6. 6.
    Janes, W., Scholz, W. and Schuster, M. (2000): Deoxynivalenol, zearalenone, ochratoxin A : Quality of feed cereals. Proceeding 22 Mykotoxin Workshop, 5 – 7 June, Bonn, Mycotoxin Research, 16A, 1, 54 - 57Google Scholar
  7. 7.
    Janes, W. and Schuster, M. (2002) : Bestimmung von Deoxynivalenol (DON) in Körperflüssigkeiten (Blut, Galle, Harn) und Kot des Schweins unter Verwendung von Immunoaffinitätssäulen und LC — UV — detektion. Mycotoxin ResearchGoogle Scholar
  8. 8.
    Pietri, A., Morlacchini, M., Bertuzzi, T., Pallaroni, L. (1999): Performance of growing pigs fed mycotoxin contaminated diets containing a new additive. Recent progress in animal production science. 1. Proc. Of the A.S.P.A. XI I I Congress, Piacenza, Italy, 21–24 June, 1999 (edited by Piva,G., Bertoni, G., Masoero, F., Bani, P., Calamari, L.), PP. 333 - 335Google Scholar
  9. 9.
    Prelusky, D.B., Gerdes, R.G., Underhill, K.L., Rotter, B.A., Jui, P.Y. and Trenholm, H.L. (1994): Effects of low — level dietary deoxynivalenol on haematological and clinical parameters of the pigs. Natural Toxins, 2 : 97 - 104PubMedCrossRefGoogle Scholar
  10. 10.
    Richter, W.I.F., Lepschy von Gleissenthal, J., Lindermayer, H., Holzer, A., Obst, A. und Gareis, M. (1996): Behandlung von mitFusarium culmorum infiziertem Winterweizen mit Konservierungsstoffen. Das wirtschaftseigene Futter, 42, 2, 143 - 160Google Scholar
  11. 11.
    Rotter, B.A., Thompson, B.K. and Lessard, M.(1995): Effects of deoxynivalenol — contaminated diet on performance and blood parameters in growing swine. Can. J. of Anim. Sci. 75, 3: 297 - 302CrossRefGoogle Scholar
  12. 12.
    Schuh, M., Binder, E.M. and Plank, B. ({dy2000}) : Experimental studies on the effect of two feed additives as detoxification of deoxynivalenol contaminated feed of growing piglets. The 16th International Pig Veterinary Congress, Melbourne, Australia, 17 – 20 Sept.Google Scholar
  13. 13.
    Shehata, S., Richter, W.I.F., Schuster, M., Scholz, W. and Nowar, M.S. (2000): Adsorption of Ochratoxin A, Deoxynivalenol and Zearalenonein vitro at different pH and adsorbents. Proceeding 22 Mykotoxin Workshop, 5 – 7 June, Bonn, Mycotoxin Research, 16A, 1, 136 - 140CrossRefGoogle Scholar
  14. 14.
    Swamy, H.V.L.N. and Devegowda, G. (1998): Ability of Mycosorb to counteract aflatoxicosis in commerical broliers. Indian J. of Poult. Sci. 33 (3) : 273 - 278Google Scholar
  15. 15.
    Shehata, S., A., M. (2001): Detoxification of Mycotoxin Contaminated Animal Feedstuffs. Thesis, Department of Animal Production, Faculty of Agriculture, Zagazig University, EgyptGoogle Scholar
  16. 16.
    Prelusky, D.B. and Trenholm, H.L. (1991) Tissue distribution of deoxynivalenol in swine dosed intravenously. J. Agric. Food Chem., 39, 748 - 751CrossRefGoogle Scholar

Copyright information

© Society of Mycotoxin Research and Springer 2004

Authors and Affiliations

  • S. Shehata
    • 1
  • W. Richter
    • 2
  • M. Schuster
    • 3
  • H. Lindermayer
    • 2
  1. 1.Dept. of Animal Prod., Fac. of Agric.Zagazig UniversityZagazig
  2. 2.Institut für Tierernährung und FutterwirtschaftBavarian State Research Center for AgriculturePoing-Grub
  3. 3.Bavarian State Research Center for Agriculture, Qualitätssicherung und Untersuchungswesen

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