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The islet-acinar axis of the pancreas

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Conclusion

Two decades after Henderson put forward his hypothesis that the remarkable arrangement of the islets of Langerhans within the exocrine pancreas has a specific purpose(2), there is no doubt that insulin regulates both metabolism and secretion of pancreatic acinar cells. Teleologically this is only sensible, because digestion, absorption, and metabolism are not separate functions of the body, but closely related. Thus nutrients in the gastrointestinal tract will stimulate insulin secretion via nervous and hormonal pathways, summarized as the entero-insular axis(124), and the insulin released will not only regulate blood glucose, but will also potentiate exocrine pancreatic secretion. In addition, insulin also stimulates other acinar cell functions, such as transport of amino acids or glucose, as well as protein and enzyme synthesis. Thus, insulin has both short-term and long-term effects on the exocrine pancreas.

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  1. Department of Gastroenterology, Medical Clinic, University Clinic Essen and Medical Clinic IV-Gastroenterology-University Clinic, Mannheim, Germany

    Jürgen v. Schönfeld, Harald Goebell & Michael K. Mütter

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Schönfeld, J.v., Goebell, H. & Mütter, M.K. The islet-acinar axis of the pancreas. Int J Pancreatol 16, 131–140 (1994). https://doi.org/10.1007/BF02944323

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