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Dermatitis herpetiformis: A review of fifty-four patients

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Summary

A review of 54 patients with dermatitis herpetiformis presenting between 1984–1993 to The Regional Centre of Dermatology, Mater Misericordiae Hospital was undertaken. All patients had skin lesions clinically and histologically typical of dermatitis herpetiformis. Deposition of granular IgA at the dermoepidermal junction on direct immunofluorescence was present in each case. The average age of onset was 41.8 yr, patients having symptoms for an average of 1.6 yr before diagnosis. Six patients had a prior history of coeliac disease. Two patients had a family history of dermatitis herpetiformis, a father and son who were both propositi in this study. Small bowel biopsy was performed on 35 patients, 71.4 per cent of them showing evidence of villous atrophy. All patients were controlled on a gluten free diet or by dapsone or a combination of these. None of the patients experienced serious adverse effects of therapy, nor did any develop lymphoma of the small bowel with a mean follow up period of 4.2 yr (range 1–10 yr).

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References

  1. Duhring, L. A. Dermatitis herpetiformis. JAMA 1884; 3: 225–229.

    Google Scholar 

  2. Zone, J. J. Dermatitis herpetiformis. Current Problems in Dermatology. 1991; 3: 18–19.

    Article  Google Scholar 

  3. Van Der Meer, J. B. Granular deposits of immunoglobulins in the skin of patients with dermatitis herpetiformis: An immunofluorescent study. Br. J. Dermatol. 1969; 81: 493–503.

    Article  PubMed  Google Scholar 

  4. Chorzelski, T. P., Beutner E. H., Jablonska, S., Blaszczyk, M., Triftshauser, C. Immunofluorescence studies in the diagnosis of dermatitis herpetiformis and its differentiation from bullous pemphigoid. J. Invest. Dermatol. 1971; 56: 373–380.

    Article  PubMed  CAS  Google Scholar 

  5. Buckley, D. B., English, J., Molloy, W., Doyle, C. T., Whelton, M. J. Dermatitis herpetiformis: a review of 119 cases. Clin. Exp. Dermatol. 1983; 8: 477–487.

    Article  PubMed  CAS  Google Scholar 

  6. Burrows, D. The prevelance of dermatitis herpetiformis. Br. J. Dermatol. 1972; 86: 437.

    Article  PubMed  CAS  Google Scholar 

  7. Everall, J. A clinical and follow up study of 53 cases of dermatitis herpetiformis with electron microscopical examination in one case. Acta Derm. Venereol. (Stockh). 1954; 34: 259–271.

    CAS  Google Scholar 

  8. Renuala, T., Lokki, J. Dermatitis herpetiformis in Finland. Acta Derm. Venereol. (Stockh). 1978; 58: 505–510.

    Google Scholar 

  9. Gawkrodger, D. J., Blackwell, J. N., Gilmour, H. M., Rifkind, E. A., Heading, R. C., Barneston, R.StC. Dermatitis herpetiformis: diagnosis, diet and demography. Gut 1984: 25: 151–157.

    Article  PubMed  CAS  Google Scholar 

  10. Wyatt, E., Shuster, S., Marks, J. A postal survey of patients with dermatitis herpetiformis. Br. J. Dermatol. 1971; 85: 511–518.

    Article  PubMed  CAS  Google Scholar 

  11. Smith, J. B., Tulloch, J. E., Meyer, L. J., Zone, J. J. The incidence and prevalence of dermatitis herpetiformis in Utah. Arch Dermatol. 1992; 128: 1608–1610.

    Article  PubMed  CAS  Google Scholar 

  12. Marks, J., Shuster, S., Watson, A. J. Small bowel changes in dermatitis herpetiformis. Lancet 1966; 2: 1280–1282.

    Article  PubMed  CAS  Google Scholar 

  13. Lawley, T. J., Strober, W., Yaoita, H., Katz, S. I. Small intestinal biopsies and HLA types in dermatitis herpetiformis patients with granular and linear IgA skin deposits. J. Invest. Dermatol. 1980; 74: 9–12.

    Article  PubMed  CAS  Google Scholar 

  14. Reunala, T. Incidence of familial dermatitis herpetiformis. Br. J. Dermatol. 1996; 134: 394–398.

    Article  PubMed  CAS  Google Scholar 

  15. Mylotte, M., Egan-Mitchell, B., Mc Carthy, C. F. et al. Incidence of coeliac disease in the west of Ireland. Br. Med. J. (Clin. Res.). 1973; 1: 703–705.

    CAS  Google Scholar 

  16. Sachs, J. A., Awad, J., McCloskey, D. et al. Different HLA associated gene combinations contribute to susceptibility for coeliac disease and dermatitis herpetiformis. Gut 1986; 27: 515–520.

    Article  PubMed  CAS  Google Scholar 

  17. Cunningham, M. J., Zone, J. J. Thyroid abnormalities in dermatitis herpetiformis. Ann Intern. Med. 1985; 102: 194–196.

    PubMed  CAS  Google Scholar 

  18. Reijonen, H., Ilonen, J., Knip, M. et al. Insulin-dependent diabetes mellitus associated with dermatitis herpetiformis: evidence for heterogenicity of HLA-associated genes. Tissue Antigens 1991; 37: 94–96.

    Article  PubMed  CAS  Google Scholar 

  19. Callen, J. P. Internal disorders associated with bullous disease of the skin. J. Am. Acad. Dermatol. 1980; 3: 107–119.

    Article  PubMed  CAS  Google Scholar 

  20. Gawkrodger, D. J., Vestey, J. P., O’Mahony, S., Marks, J. M. Dermatitis herpetiformis and established coeliac disease. Br. J. Dermatol. 1993; 129: 694–695.

    Article  PubMed  CAS  Google Scholar 

  21. Fry, L., Keir, P., McMinn, R. M. H., Cowan, J. D., Hoffbrand, A.V. Small intestinal structure and function and haematological changes in dermatitis herpetiformis. Lancet 1967; 2: 729–733.

    Article  PubMed  CAS  Google Scholar 

  22. Sigurgeirsson, B., Agnarsson, B. A., Lindelof, B. Risk of lymphoma in patients with dermatitis herpetiformis. Br. Med.J. 1994; 308: 13–15.

    CAS  Google Scholar 

  23. Lewis, H. M., Renaula, T. L., Garioch, J. J. et al. Protective effect of gluten-free diet against development of lymphoma in dermatitis herpetiformis. Br. J. Dermatol. 1996; 135: 363–367.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Regional Centre of Dermatology, Mater Misericordiae Hospital, Dublin 7

    C. A. Egan, S. O’Loughlin, S. Gormally & F. C. Powell

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  1. C. A. Egan
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  2. S. O’Loughlin
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  3. S. Gormally
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  4. F. C. Powell
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Egan, C.A., O’Loughlin, S., Gormally, S. et al. Dermatitis herpetiformis: A review of fifty-four patients. I.J.M.S. 166, 241–244 (1997). https://doi.org/10.1007/BF02944243

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