Irish Journal of Medical Science

, Volume 166, Issue 4, pp 239–240 | Cite as

Carbimazole induced agranulocytosis: Rescue with human recombinant Granulocyte Colony Stimulating factor

  • J. A. O’Hare
  • T. Azher


We report on a 25 yr old woman with primary autoimmune hyperthyroidism who was treated with carbimazole. Forty-three days later she developed agranulocytosis (64 × 106/l). With 4 days treatment with recombinant human Granulocyte Colony Stimulating factor the granulocyte count rose to normal — 4,350 cells X 106/l. This is considerably faster than the rate of spontaneous recovery which usually takes one to 2 weeks.


Agranulocytosis Leucocyte Count Infectious Mononucleosis Methimazole Carbimazole 
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Copyright information

© Springer 1997

Authors and Affiliations

  • J. A. O’Hare
    • 1
    • 2
  • T. Azher
    • 1
    • 2
  1. 1.Department of MedicineLimerick Regional General HospitalIreland
  2. 2.University College CorkIreland

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