Carbimazole induced agranulocytosis: Rescue with human recombinant Granulocyte Colony Stimulating factor
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We report on a 25 yr old woman with primary autoimmune hyperthyroidism who was treated with carbimazole. Forty-three days later she developed agranulocytosis (64 × 106/l). With 4 days treatment with recombinant human Granulocyte Colony Stimulating factor the granulocyte count rose to normal — 4,350 cells X 106/l. This is considerably faster than the rate of spontaneous recovery which usually takes one to 2 weeks.
KeywordsAgranulocytosis Leucocyte Count Infectious Mononucleosis Methimazole Carbimazole
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