Irish Journal of Medical Science

, Volume 166, Issue 4, pp 239–240 | Cite as

Carbimazole induced agranulocytosis: Rescue with human recombinant Granulocyte Colony Stimulating factor

  • J. A. O’Hare
  • T. Azher


We report on a 25 yr old woman with primary autoimmune hyperthyroidism who was treated with carbimazole. Forty-three days later she developed agranulocytosis (64 × 106/l). With 4 days treatment with recombinant human Granulocyte Colony Stimulating factor the granulocyte count rose to normal — 4,350 cells X 106/l. This is considerably faster than the rate of spontaneous recovery which usually takes one to 2 weeks.


Agranulocytosis Leucocyte Count Infectious Mononucleosis Methimazole Carbimazole 


  1. 1.
    Herbert, V. The Blood (Thyroid disease: disorders that cause thyrotoxicosis) in: Werner’s The Thyroid. Ed S. H. Ingbar and L. E. Bravermann. 5th Edition. J. P. Lippincott. Philadelphia. 1986. PP. 878–884.Google Scholar
  2. 2.
    Tajiri, J., Noguchi, S., Murakami, T., Murakami, N. Antithyroid drug-induced agranulocytosis. Arch. Intern. Med. 1990; 150: 621–624.PubMedCrossRefGoogle Scholar
  3. 3.
    Cooper, D. S. Antithyroid drugs. N. Engl. J. Med. 1984; 311: 1353–1362.PubMedGoogle Scholar
  4. 4.
    Weitzman, S. A., Stossel, T. P. Drug induced immunological neutropaenia. Lancet 1978; 11: 1068–1072.CrossRefGoogle Scholar
  5. 5.
    Metcalf, D. Haemopoietic growth factors 2: Clinical applications. Lancet 1989; 11: 885–887.CrossRefGoogle Scholar
  6. 6.
    Heinrich, B., Gross, M., Goebel, F. D. Methimazole-induced agranulocytosis and granulocyte-colony stimulating factor. Ann. Intern. Med. 1989; 111: 621–622.PubMedGoogle Scholar
  7. 7.
    Tamai, H., Mukuta, T., Matsubayashi, S. et al. Treatment of methimazole-induced agranulocytosis using human granulocyte colony stimulating factor (rhg-CSF). J. Clin. Endocrin. Metab. 1993; 77: 1356–1360.CrossRefGoogle Scholar

Copyright information

© Springer 1997

Authors and Affiliations

  • J. A. O’Hare
    • 1
    • 2
  • T. Azher
    • 1
    • 2
  1. 1.Department of MedicineLimerick Regional General HospitalIreland
  2. 2.University College CorkIreland

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