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Irish Journal of Medical Science (1926-1967)

, Volume 41, Issue 11, pp 515–517 | Cite as

Localisation of sites of catabolism of intravenously administered proteins

  • Michael G. Harrington
  • Walter L. Hughes
Article

Summary

From the observations outlined above it would seem reasonable to postulate that the treatment of ribonuclease with chromium 51 resulted in the formation of at least two labelled derivatives. Their presence was indicated by the behaviour of the preparation on membrane dialysis, a procedure which likewise indicated the presence of two very similar components in the native enzyme. Thein vivo fractionation of the injected preparation also pointed to the presence of at least two components, one of which was concentrated in the kidneys, the other in the liver. The available evidence supported the organ-specificity of these two fractions.

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References

  1. Craig, L. C. and Konigsberg, W. (1961).J. Phys. Chem., 65, 166.CrossRefGoogle Scholar
  2. Harrington, M. G. and Hughes, W. L. (1964).Fed. Proc., 23, 2188.Google Scholar
  3. McFarlane, A. S. (1957).Progr. Biophysics, 7, 115.Google Scholar
  4. Schultze, B. and Hughes, W. L. (1963).Fed. Proc., 22, 1548.Google Scholar

Copyright information

© Springer 1966

Authors and Affiliations

  • Michael G. Harrington
    • 1
  • Walter L. Hughes
    • 2
  1. 1.Department of BiochemistryUniversity CollegeDublin
  2. 2.Department of PhysiologyTufts University School of MedicineBostonUSA

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