Irish Journal of Medical Science

, Volume 165, Issue 1, pp 41–43 | Cite as

Staphylococcus aureus sensitivity to various antibiotics — A national survey in Ireland 1993

  • E. Moorhouse
  • L. Fenelon
  • R. Hone
  • E. Smyth
  • J. McGahon
  • M. Dillon


The sensitivity ofStaphylococcus aureus (S. aureus) to methicillin, penicillin, gentamicin, erythromycin, ciprofloxacin, fusidic acid and mupirocin was tested in 1152 clinical isolates from nine hospital microbiology departments. In all cases standard methods for culture and sensitivity were employed using either the Stokes’ or a modified Stokes’ method for susceptibility testing. The isolates were recovered from 1150 patients (606 men, 544 women; mean age: 41 years) and only those deemed relevant to the patient’s clinical condition were included. Of the total 1152 isolates, 454 were regarded as hospital acquired, 506 were community acquired and the source of the remaining 192 isolates was unknown. The overall percentages ofS. aureus sensitive to the tested antibiotics were as follows: methicillin 85%, penicillin 8%, gentamicin 89%, ciprofloxacin 85%, erythromycin 80%, fusidic acid 96%, mupirocin 98%. The sensitivity of the methicillin resistant strains to the other antibiotics tested was generally low except for fusidic acid and mupirocin, both of which retain good activity against methicillin resistantS. aureus (MRSA). Participating investigators


Gentamicin Erythromycin Methicillin Mupirocin Fusidic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Shanson, D. C. Clinical relevance of resistance to fusidic acid inS. aureus. J. Antimicrob. Chemother. 1990; 25, Suppl. B: 15–21.PubMedGoogle Scholar
  2. 2.
    Faber, M., Rosdahl, V. T. Susceptibility to fusidic acid among DanishS. aureus strains and fusidic acid consumption. J. Antimicrob. Chemother. 1990; 25 Suppl. B: 7–14.PubMedGoogle Scholar
  3. 3.
    Cookson, B. D., Lacey, R. W., Noble, W. C. Mupirocin resistantS. aureus. Lancet 1990; 335: 1095–96.PubMedCrossRefGoogle Scholar
  4. 4.
    Gilbart, J., Perry, C. R., Slocombe, B. High level mupirocin resistance inS. aureus: evidence for two isoleucyl - tRNA synthetases. Antimicrob. Agents and Chemother. 1993; 37: 32–38.Google Scholar
  5. 5.
    Heffernan, H. M., Anderson, D. M. Antibiotic resistance amongS. aureus in New Zealand. N. Z. Med. J. 1984; 97: 418–419.PubMedGoogle Scholar
  6. 6.
    Atkinson, B. A. Species incidence and trends in susceptibility to antibiotics in the United States and countries: MIC and MBC In: Lorian, V. Antibiotics in laboratory medicine: Williams and Wilkins, New York 1986; 995–1162.Google Scholar
  7. 7.
    Varaldo, P. E., Cipriani, P., Foca, A. et. al. Identification, clinical distribution, and susceptibility to methicillin and 18 additional antibiotics of clinical Staphylococcus isolates: nationwide investigation in Italy. J. Clin. Microbiol. 1984; 19: 838–843.PubMedGoogle Scholar
  8. 8.
    Turnidge, J., Lawson, P., Benn, R. A. National survey of antimicrobial resistance inS. aureus in Australian teaching hospitals. Med. J. Aust. 1989; 150: 65–72.PubMedGoogle Scholar
  9. 9.
    Spencer, R. C., Wheat, P. F., Magee, J. T., Brown, E. H. A. three year survey of clinical isolates in the United Kingdom and their antimicrobial susceptibility. J. Antimicrob. Chemother. 1990; 26: 435–446.PubMedCrossRefGoogle Scholar
  10. 10.
    Cafferkey, M. T., Hone, R., Coleman, D. et. al. Methicillin resistantS. aureus in Dublin 1971-1984. Lancet 1985; 2: 705–708.PubMedCrossRefGoogle Scholar
  11. 11.
    George, R. C., Ball, L. C., Norbury, P. B. Susceptibility to ciprofloxacin of nosocomial Gram-negative bacteria and staphylococci isolated in the UK. J. Antimicrob. Chemother. 1990; 26 Suppl F: 145–156.PubMedGoogle Scholar
  12. 12.
    Smith, S. M., Eng, R. H., Bais, P., Fan-Harvard, P., Tecson-Tumang, F. et al. Epidemiology of ciprofloxacin resistance among patients with methicillin resistantS. aureus. J. Antimicrob. Chemother. 1990; 26: 567–572.PubMedCrossRefGoogle Scholar
  13. 13.
    Aspock, A., Roller, W., Rotter, M. et al. Resistensverhalten von Staphylokokken ain Allgemeinen Krankenhaus der Stadt Wien (Juli bis Dezember 1991). Wien Klin Wochenschr 1994; 106/1: 20–26.Google Scholar

Copyright information

© Springer 1996

Authors and Affiliations

  • E. Moorhouse
    • 1
  • L. Fenelon
    • 2
  • R. Hone
    • 3
  • E. Smyth
    • 4
  • J. McGahon
    • 5
  • M. Dillon
    • 5
  1. 1.Department of MicrobiologyRoyal College of Surgeons in IrelandDublin 2
  2. 2.Department of MicrobiologySt. Vincent’s HospitalDublin 4
  3. 3.Department of MicrobiologyMater HospitalDublin 7
  4. 4.Department of MicrobiologyBeaumont HospitalDublin 9
  5. 5.Medical DepartmentLeo Laboratories LimitedDublin 12

Personalised recommendations