Some observations on clinical reactions following smallpox vaccination

  • Geoffrey J. Bourke
  • Noel Clarke


The clinical reactions and symptomatology following the successful smallpox vaccination of 736 university students are outlined.

No significant association was demonstrated between illness and sex, vaccination technique, or scar area from previous vaccination. A significant association exists between illness, the interval since last vaccination, type of reaction, the first appearance of the reaction, and the size of the lesion produced by vaccination.

The advantages cited for the multiple pressure method, as compared with the scratch method of vaccination are discussed.


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Copyright information

© Springer 1964

Authors and Affiliations

  • Geoffrey J. Bourke
    • 1
  • Noel Clarke
    • 1
    • 2
  1. 1.Trinity CollegeDublin
  2. 2.National Institutes of HealthMarylandUSA

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