Abstract
Treated the experimental acute liver injury rat induced by D-galactosamine with magnesium lithosperamate-B could significantly lower the serum activity of alanine transaminase and aspartate aminotransferase, relieve the necrosis of hepatocytes and elevate the levels of products of arachidonic acid (6-ke-to-prostaglandin 1α, prostaglandin D2 and the total prostaglandin) in liver. These results suggested that magnesium lithosperamate B was one of the main components ofSalvia miltiorrzae in treating liver injury, the action on elevating the total prostaglandin in liver might be its mechanism.
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Reference
Tanka T, et al. Magnesium and ammonium-potassium lithospermates, the active principles having a ureria-preventive effect from Salvia miltiorrhiza. Chem Pharm Bull 1989;37:340.
Yokozawa T, et al. Effect of magnesium lithospermate B on urinary prostaglandins in rats with renal failure. J Natural Products 1990; 53:662.
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Lin, P., Yasuhiro, M. & Seiji, M. Effect of magnesium lithosperamate B on D-galactosamine induced liver injury in rats. CJIM 1, 291–293 (1995). https://doi.org/10.1007/BF02940702
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DOI: https://doi.org/10.1007/BF02940702