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Effect of magnesium lithosperamate B on D-galactosamine induced liver injury in rats

  • Lin Ping 
  • Yasuhiro Mizoguzhi 
  • Seiji Morisawa 
Experimental Work And Research
  • 19 Downloads

Abstract

Treated the experimental acute liver injury rat induced by D-galactosamine with magnesium lithosperamate-B could significantly lower the serum activity of alanine transaminase and aspartate aminotransferase, relieve the necrosis of hepatocytes and elevate the levels of products of arachidonic acid (6-ke-to-prostaglandin 1α, prostaglandin D2 and the total prostaglandin) in liver. These results suggested that magnesium lithosperamate B was one of the main components ofSalvia miltiorrzae in treating liver injury, the action on elevating the total prostaglandin in liver might be its mechanism.

Key Words

Radix Salviae miltiorrhizae magnesium lithosperamate B D-galactosamine liver injury prostaglandin 

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Reference

  1. 4.
    Tanka T, et al. Magnesium and ammonium-potassium lithospermates, the active principles having a ureria-preventive effect from Salvia miltiorrhiza. Chem Pharm Bull 1989;37:340.Google Scholar
  2. 5.
    Yokozawa T, et al. Effect of magnesium lithospermate B on urinary prostaglandins in rats with renal failure. J Natural Products 1990; 53:662.CrossRefGoogle Scholar

Copyright information

© The Chinese Journal of Integrated Traditional and Western Medicine Press 1995

Authors and Affiliations

  • Lin Ping 
    • 1
  • Yasuhiro Mizoguzhi 
    • 2
  • Seiji Morisawa 
    • 2
  1. 1.Liver Diseases Research CenterShanghai Academy of Traditional Chinese MedicineShanghai
  2. 2.Division of biochemistry, Department of MedicineOsaka City UniversityJapan

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