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Irish Journal of Medical Science

, Volume 140, Issue 10, pp 449–454 | Cite as

Evaluation of malabsorption test using14c triglyceride

  • G. H. Tomkin
  • T. K. Bell
  • D. R. Hadden
Article

Summary

A FURTHER evaluation of the14C fat absorption test is reported.14C blood levels have been measured during the test and give good separation between normal controls and the patients with malabsorption. However, patient to patient variation within each group was greater than when the14CO2 was measured in the breath. The lower14CO2excretion and14C blood levels found in obese subjects have been further investigated and the results are discussed. It is concluded that this test may replace the routine estimation of faecal fat on a three-day collection in the investigation of a patient with suspected malabsorption. We wish to thank Dr. D. A. D. Montgomery for his helpful criticism. We would also like to thank Mr. S. J. Todd for technical assistance in the14C estimations.

Keywords

Obese Patient Palmitic Acid Gastric Emptying Obese Subject IRISH Journal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bhatia, S. K., Bell, T. K., Love, A. H. G. and Montgomery, D. A. D. 1969. An evaluation of a test using14C labelled triglyceride in the diagnosis of steatorrhoea. Irish J. med. Sci. No. 11, 545–552.Google Scholar
  2. Dawson, A. M., Gallagher, N., Saunders, D. R. and Webb, J. 1964. In: Dawson, R. M. C. and Rhodes, D. N. ed. Metabolism and physiological significance of lipids. Wiley, London 243.Google Scholar
  3. Dole, V. P. A. 1956. A relation between non esterified fatty acids in plasma and the metabolism of glucose. J. clin. Invest. 35, 150–154.PubMedCrossRefGoogle Scholar
  4. Gordon, E. S., Goldberg, E. M., Brandabur, J. J., Gee, J. N. L. and Rankin, J. 1962. Abnormal energy metabolism in obesity. Trans. Ass. Amer. Phycns. 75, 118–128.Google Scholar
  5. Hales, C. N. and Randle, P. J. 1963. Immunoassay of insulin with insulin antibody precipitate. Biochem. J., 88, 137–146.PubMedGoogle Scholar
  6. Hyun, S. A., Vahouny, G. V. and Treadwell, C. R. 1967. Portal absorption of fatty acids in lymph and portal vein cannulated rats. Biochem. biophys. Acta. (Amst.) 137, 296–305.Google Scholar
  7. Jungas, R. L. and Ball, E. G. 1963. Studies on the metabolism of adipose tissue. XII: The effects of insulin and ephinephrine on free fatty acids and glycerol production in the presence and absence of glucose. Biochemistry 2, 383–388.CrossRefGoogle Scholar
  8. Kaihara, S. and Wagner, H. N. 1968. Measurement of intestinal fat absorption with carbon-14 labelled tracers. J. Lab. clin. Med. 71, 400–411.PubMedGoogle Scholar
  9. Karam, J. H., Grodsky, G. M. and Forsham, P. H. 1963. Excessive insulin response to glucose in obese subjects as measured by immunochemical assay. Diabetes 12, 197–204.PubMedGoogle Scholar
  10. McKelvey, S. T. D. 1970. Gastric incontinence and post-vagotomy diarrhoea. Brit. J. Surg. 57, 741–747.PubMedCrossRefGoogle Scholar

Copyright information

© Springer 1971

Authors and Affiliations

  • G. H. Tomkin
    • 1
  • T. K. Bell
    • 1
  • D. R. Hadden
    • 1
  1. 1.The Metabolic Unit and Medical Physics DepartmentRoyal Victoria HospitalBelfast

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