Irish Journal of Medical Science

, Volume 153, Issue 11, pp 385–388 | Cite as

Haemoglobin solution as an oxygen-carrying resuscitation fluid in haemorrhagic shock

  • William Odling-Smee
  • Conor McLarnon


A SOLUTION of pyridoxalated haemoglobin has been prepared and tested in an animal shock model by comparing its efficiency in resuscitating an animal from hypovolaemic shock with dextran. It is as efficient as dextran in restoring blood pressure, and makes more oxygen available to the tissues. Great care must be exercised in the preparation of the haemoglobin solution.


Dextran Central Venous Pressure Plasma Expander Restore Blood Pressure Colloid Osmotic Pressure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Benesch, R. E., Benesch, R., Renthal, R. D., Maeda, V. 1972. Affinity labelling of the polyphosphate binding site of haemoglobin. Biochemistry 11, 3576–3582.PubMedCrossRefGoogle Scholar
  2. Bonhard, K. 1975. Acute oxygen supply by infusion of haemoglobin solution. Fed. Proc. 34, 1466.PubMedGoogle Scholar
  3. DeVenuto, F., Moores, W. Y., Zegna, A. al. 1977. Total and partial blood exchange in the fat with haemoglobin prepared by crystallization. Transfusion 17, 555.CrossRefGoogle Scholar
  4. DeVenuto, F. 1982. Haemoglobin solutions as oxygen-delivering resuscitation fluids. Crit. Care Med. 10, 238–245.PubMedCrossRefGoogle Scholar
  5. DeVenuto, F., Zegna, A. 1983. Preparation and evaluation of pyridoxalated-polymerised human haemoglobin. J. Surg. Res. 34, 205–212.PubMedCrossRefGoogle Scholar
  6. Greenburg, A. G., Schooley, M., Peskin, G. W. 1977. Improved retention of stroma-free haemoglobin solution by chemical modification. J. Trauma 17, 501.PubMedCrossRefGoogle Scholar
  7. Greenburg, A. G., Schooley, M., Ginsburg, K. A., Peskin,.G. W. 1978. Pyridoxalated stroma-free haemoglobin solution in the resuscitation of haemorrhagic shock. Surg. Forum 29, 44–46.PubMedGoogle Scholar
  8. Gruber, V. F. 1969. Blood replacement. Springer-Verlog, Berlin.Google Scholar
  9. Huestis, D. W., Boue, J. R., Busch, S. 1976. Practical Blood Transfusion. 2nd ed. Little, Brown & Co., Boston.Google Scholar
  10. Moss, G. S., Der Woskin, R., Cochin, A. 1973. Stroma-free haemoglobin. Preparation and observation in vitro changes in coagulation. Surgery 74, 198.PubMedGoogle Scholar
  11. Peskin, G. W., O’Brien, K., Rabiner, S. F. 1969. Stroma-free haemoglobin: the ‘ideal’ blood substitute? Surgery 66, 185.PubMedGoogle Scholar
  12. Rabiner, S. F., Helbert, J. R., Lopas, al. 1967. Evaluation of stroma-free haemoglobin for use as a plasma expander. J. Exp. Med 126, 1127.PubMedCrossRefGoogle Scholar
  13. Wiggers, C. J. E. 1942. The present status of the shock problem. Physiol, res. 22, 74–123.Google Scholar

Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • William Odling-Smee
    • 1
  • Conor McLarnon
    • 1
  1. 1.Departments of Surgery and HaemotologyThe Queen’s University of BelfastIreland

Personalised recommendations