Summary
The clinical and autopsy findings of 5 cases of diffuse alveolar damage (DAD) are presented. The associated conditions were trauma (2 cases), endotoxic shock, spinal cord infarction and complicated major surgery. Attention is drawn to the role of oxygen therapy in the evolution of the lung lesion and an attempt is made to quantify the amount of oxygen in terms of units of toxicity.
Similar content being viewed by others
References
Gould, V. E., Tosco, R., Wheelis, R. F., Gould, N. S. and Kapanchi, Y. 1972. Oxygen pneumonitis in man. J. Lab. Invest. 26, 499.
Katzenstein, A., Bloor, C. M. and Leibow, A. A. 1976. Diffuse alveolar damage—the role of oxygen, shock and related factors. Am. J. Path. 85, 210.
Mills, Mitchell. 1968. Pulmonary effects of nonthoracic trauma. J. Trauma. 8, 651.
Moss, G. S., Das Gupta, T. K., Newson, B. S. and Nyhus, L. M. 1972. Morphologic changes in the primate lung after haemorrhagic shock. Surg. Gynec. Obs. 131, 3.
Nash, G., Foley, F. D. and Langlinais, P. C. 1974. Pulmonary interstitial oedema and hyaline membranes in adult burn patients. Human Path. 5, 149.
Pratt, P. C., Vollmer, R. T., Shelburne, J. D. and Crapo, J. D. 1979. Pulmonary morphology in a multihospital collaborative extracorporeal membrane oxygenation project. Am. J. Path. 95, 191.
Shilling, C. W., Werts, M. F. and Schandelmeir, N. R. 1976.In The Underwater Handbook. New York. Plenum Press. p. 162.
Sevitt, S. 1974. Diffuse and focal pneumonitis. J. Clin. Path. 27, 21.
Wright, W. B. 1972. Use of the University of Pensylvania, Institute for environmental medicine procedure for calculation of cumulative pulmonary oxygen toxicity. U.S. Navy Exp. Diving Unit Report. NEDU-2-72.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gough, J.C., Connolly, C.E., Kennedy, J.D. et al. Diffuse alveolar damage. IJMS 149, 343–345 (1980). https://doi.org/10.1007/BF02939168
Issue Date:
DOI: https://doi.org/10.1007/BF02939168