Irish Journal of Medical Science

, Volume 149, Issue 1, pp 261–265 | Cite as

The effects of intrauterine exposure to stilboestrol on the cervicovaginal epithelia

  • J. F. Murphy


THE epithelial disposition of the lower genital tract in 10 females exposed to diethylstilboestrol (DES)in utero was studied. Significant deviations from the normal pattern were found including the development of squamous carcinomain situ in one patient.


Columnar Epithelium Anterior Vaginal Wall Transformation Zone Positive Cytology Clear Cell Adenocarcinoma 
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  1. Aldrich, J., Henderson, B. E., Townsend, D. 1972. Diagnostic procedures for the stilbestrol adenosis carcinoma syndrome. N. Eng. J. Med. 287, 934.Google Scholar
  2. Bonney, V., Glendinnig, B. 1911. Adenomatasis vaginae: a hitherto undescribed condition. Proc. Roy. Soc. Med. 4, 18.Google Scholar
  3. Burke, L., Antonioli, D., Rosen, S. 1978. Vaginal and cervical squamous cell dysplasia in women exposed to diethylstilbestrolin utero. Am. J. Obstet. Gynec. 132, 537.PubMedGoogle Scholar
  4. Fetherston, W. C. 1975. Squamous neoplasia of vagina related to DES syndrome. Am. J. Obstet. Gynec. 122, 176.PubMedGoogle Scholar
  5. Fetherston, W. C., Meyers, A., Speckbard, M. E. 1972. Adenocarcinoma of the vagina in young women. The stilboestrol-adenosis-adenocarcinoma of the vagina syndrome. Wis. Med. J. 71, 87.PubMedGoogle Scholar
  6. Herbst, A. L., Jurman, R. J., Scully, R. E., Poskanzer, D. C. 1972. Clear cell adenocarcinoma of the genital tract in young females. Registry Report. N. Eng. J. Med. 287, 1259.Google Scholar
  7. Herbst, A. L., Norvsis, M. J., Rosenow, P. J., Welsh, W. R. and Scully, R. E. 1979. An analysis of 346 cases of clear cell adenocarcinoma of the vagina and cervix with emphasis on survival. Gynecol. Oncol. 7, 111.PubMedCrossRefGoogle Scholar
  8. Kraatz, H. 1939. Farbfiltervorsbaltung zur Leiditeren erlenung der kolposkopie. Zentralblatt fur Gynaekolgie. 63, 2307.Google Scholar
  9. Lane, V. and Dohnal, V. 1961. Ektopie auf der scheidenschlermhaut. Neoplasia 8, 433.Google Scholar
  10. Linhartova, A. 1972. A comparative study of the morphology and evolution of congenital and adult ectopy of the uterine cervix. Plzn Lek Sboru. 37, 85.Google Scholar
  11. Pixley, E. 1976. Morphology of the fetal and prepubertal cervicovaginal epithelium.In The Cervix. Ed. Jordan and Singer. Saunders, London, p. 75.Google Scholar
  12. Plaut, A., Dreyfuss, M. L. 1940. Adenosis of vagina and its relation to primary adenocarcinoma of vagina. Surg. Gynecol. Obstet. 71, 756.Google Scholar
  13. Pomerance, N. 1973. Post-stilboestrol secondary syndrome. Obstet. Gynec. 42, 12.PubMedGoogle Scholar
  14. Sandberg, E. C., Damielson, R. W. and Cauwet, R. W. 1985. Am. J. Obstet. Gynecol. 9, 209.Google Scholar
  15. Stafl, A. and Mattingly, R. F. 1976. Diethylstilboestrol and the Cervico-vaginal Epithelium.In The Cervix. Ed. Jordan and Singer. Saunders, London, p. 345.Google Scholar
  16. Stafl, A., Mattingly, R. F., Foley, D. V. and Fetherston, W. C. 1974. Clinical diagnosis of vaginal adenosis. Obstet. Gynecol. 43, 118.PubMedGoogle Scholar
  17. Von Preuschen. 1877. Uber cystenbildang in der vagina. Arch Pathol. Anal. 70, 111.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • J. F. Murphy
    • 1
  1. 1.National Maternity HospitalDublin

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