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Erroneous plasma “cortisol” values in Addison’s disease

A problem of the fluorimetric assay of 11-OH corticosteroids
  • G. MacFlynn
  • G. D. Johnston
  • D. G. McDevitt
  • D. R. Hadden
Case Report
  • 13 Downloads

Summary

A case is described in which a woman, being investigated for Addison’s disease, had what appeared initially to be plasma cortisol levels within the normal range. Subsequent investigations including ACTH stimulation and an immunofluorescent test for adrenal cortical antibodies showed the diagnosis to be correct. Attention is drawn to the lack of specificity of the fluorimetric plasma 11-OH corticosteroid assay and, therefore, to the danger of using plasma “cortisol” as a screening test for adrenocortical hypofunction.

Keywords

Cortisol Corticosterone Plasma Cortisol Level Royal Victoria Hospital Synacthen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Ernest, I. 1966. Steroid excretion and plasma cortisol in 41 cases of Cushing’s syndrome. With data on corticotrophin and metapyron tests. Acta Endocrinol. 51, 511.PubMedGoogle Scholar
  2. Mattingly, D. 1962. A simple fluorometric method for the estimation of free 11-hydroxycorticoids in human plasma. J. Clin. Path. 15, 374.PubMedCrossRefGoogle Scholar
  3. Mattingly, D. and Tyler, C. 1967. Simple screening test for Cushing’s syndrome. Brit. med. J. iv, 394.CrossRefGoogle Scholar
  4. Montgomery, D. A. D. and Welbourn, R. B. 1975. Medical and Surgical Endocrinology. London, Arnold, p. 96.Google Scholar

Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • G. MacFlynn
    • 1
    • 2
    • 3
  • G. D. Johnston
    • 1
    • 2
    • 3
  • D. G. McDevitt
    • 1
    • 2
    • 3
  • D. R. Hadden
    • 1
    • 2
    • 3
  1. 1.Department of Therapeutics and PharmacologyQueen’s UniversityBelfast
  2. 2.Belfast City HospitalBelfast
  3. 3.Royal Victoria HospitalBelfast

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