The effect of temperature on the sensitivity to noradrenaline of isolated perfused ear and mesenteric arteries of ox, sheep and pig
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RESPONSES to graded doses of noradrenaline were obtained from isolated perfused arteries of the ox, sheep and pig at 38–39, 35, 30, 20 and 10°C. The sensitivity of ox and sheep ear arteries from animals exposed to an environmental temperature of approximately 5°C was maximal at 20°C. The sensitivity of ox and sheep mesenteric arteries was maximal at 38–39°C, as was the sensitivity of ear arteries from pigs exposed to an environmental temperature of 27°C.
It is suggested that the temperature at which isolated mammalian arteries show maximal sensitivity to noradrenaline may be related to the local temperature to which they were previously exposed in the intact animal.
KeywordsMesenteric Artery Environmental Temperature Pressure Rise IRISH Journal Perfuse Artery
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- Bazett, H. C., Love, L., Newton, M., Eisenberg, L., Day, R. and Forster, R. 1948. Temperature changes in blood flowing in arteries and veins in man. J. appl. Physiol. 1, 3.Google Scholar
- Joyce, C. M. 1967. The effect of environmental temperature on succinic dehydrogenase activity in the ear skin of the rabbit. Proc. R. Ir. Acad., 65, B, 425.Google Scholar
- McClelland, R. J., McGrann, S. and Wallace, W. F. M. 1969. Evidence that the responses of the perfused rabbit ear artery are influenced by the environmental conditions of the animal. J. Physiol., 205, 5P.Google Scholar
- Martin, R. P. and Wallace, W. F. M. 1970. The effect of temperature on the response of the perfused rabbit ear artery to electrical stimulation. J. Physiol., 207, 80P.Google Scholar
- Surgeon, I. C. and Wallace, W. F. M. 1971. Effect of temperature on the sensitivity to noradrenaline of superficial and deep muscular arteries in the cow, sheep and pig. Ir. J. med. Sci., 140, 419.Google Scholar
- Wade, D. N. and Beilin, L. J. 1970. Vascular resistance in the perfused isolated rat tail. Br. J. Pharmac., 38, 20.Google Scholar