Urinary erythropoietin levels in normal, anaemic, polycythaemic, and uraemic subjects
The erythropoietin content of 24 hour urine collections has been assayed in a number of clinical conditions and in five normal subjects Low erythropoietin levels were found in polycythaemia vera, anaemia associated with uraemia and rheumatoid arthritis. High levels were found in association with hypoxic polycythaemia and anaemia due to iron deficiency, blood loss and marrow hypoplasia. In addition significant quantities of erythropoietin were found in renal cyst fluid and in the isotonic extract of a uterine leiomyoma removed from patients with polycythaemia.
KeywordsIron Deficiency Erythropoietin Leiomyoma Uterine Leiomyoma Chronic Uraemia
- Finne, P. H. 1965. Erythropoietin in concentrates of urine from healthy persons. Brit. med. J. i, 697.Google Scholar
- Fisher, J. W. 1972. Erythropoietin: pharmacology, biogenesis and control of production. Pharm. Reviews., 24, 459.Google Scholar
- Mirand, E. A., Weintraub, A. H., Gordon, A. S., Prentice, T. C. and Grace, J. T. 1965. Erythropoietic activity of untreated and deproteinized normal human plasma. Proc. Soc. Exptl. Biol. Med. 118, 823.Google Scholar
- Reissman, K. R. 1950. Studies on the mechanisms of erythropoietic stimulation in parabiotic rats during hypoxia. Blood. 5, 372.Google Scholar
- Stucky, W. J., Fisher, J. W., Lindholm, D., Beltran, G. and Lertora, J. J. L. 1972. Fifth Annual Renal Dialysis Contractors Conference, P. 143 a, NIAMD, Bethesda, Md.Google Scholar