Ricerca in clinica e in laboratorio

, Volume 10, Issue 3, pp 511–519 | Cite as

Immunoreactive trypsin on dried-blood spots as a possible neonatal test for cystic fibrosis

I. Evaluation of the method and preliminary field trial
  • Roberto Dominici
  • Fabrizio Monaco
  • Silvana Morano
  • Italo Antonozzi
Original Contributions


A method for blood spot immunoreactive trypsin (IRT) determination suitable for neonatal mass screening, and the preliminary steps towards its large-scale application are described. The method showed a highly significant correlation between blood spot and plasma values, and a study of plasma reference values in a population of 1,050 newborn infants demonstrated a log-normal distribution with a mean IRT concentration of 238.3 ng/ml. The results and their implications for neonatal mass screening are discussed.


Cystic fibrosis Immunoreactive trypsin Neonatal test 


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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • Roberto Dominici
    • 1
  • Fabrizio Monaco
    • 1
  • Silvana Morano
    • 2
  • Italo Antonozzi
    • 2
  1. 1.Istituto di Neuropsichiatria Infantile, Centro delia TiroideUniversità degli Studi di RomaItalia
  2. 2.Centro di Medicina Sociale per le Oligofrenie Dismetaboliche Istituto di Neuropsichiatria InfantileUniversità degli Studi di RomaRomaItalia

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