International Journal of Pancreatology

, Volume 4, Issue 3, pp 291–301 | Cite as

Changes in microvascular structure of the fibrotic pancreas and their influence on pancreatic endocrine function

  • Tanoshi Yatagai
  • Takashi Suzuki
  • Takayoshi Tobe


The objectives of this study were to clarify the microvascular structure in and around the Langerhans’ islands of the normal pancreas, elucidate how the structure changes with advance of pancreatic fibrosis owing to stagnation of pancreatic juice, and how these changes influence the endocrine function of the pancreas. For these purposes, the changes in microvascular structure of the fibrotic pancreas, produced by ligation of the pancreatic duct in mongrel adult dogs, were investigated by microangiography and injection replica scanning electron microscopic methods. In addition, the endocrine function of the pancreas was studied by the intravenous (iv) glucose tolerance test. The results revealed that the basic blood vessel structure of the Langerhans’ islands, and its insulin secretory function, were maintained relatively well in the long-term, duct-ligated pancreas though the capillary network spreading in the pancreatic exocrine part could hardly be observed.

Key Words

Pancreas, microangiograph of pancreas, microvascular structure of injection replica scanning electron microscopic method 


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Copyright information

© Humana Press Inc. 1989

Authors and Affiliations

  • Tanoshi Yatagai
    • 1
  • Takashi Suzuki
    • 2
  • Takayoshi Tobe
    • 2
  1. 1.Department of SurgeryShimada Municipal HospitalNoda, Shizuoka Pref.Japan
  2. 2.lst Department of SurgeryKyoto University School of MedicineKyotoJapan

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