Medical management of the male factor in infertility

  • W. Thompson
  • A. I. Traub


A Simple scheme for investigation of the male partner is discussed in terms of history, physical examination and specific diagnostic tests. A review of the treatment of oligospermia is presented in 2 sections: drug therapy and physical methods for improving the quality of semen in preparation for artificial insemination. These include column extraction and split ejaculation. The place of artificial insemination, both homologous and donor, in conjuction with sperm banking is also discussed.


Sperm Motility Varicocele Sperm Count Male Infertility Artificial Insemination 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Barwin, B. N., Clarke, S. D., Biggart, J. D. and Lamont, A. 1973. Mesterolone in the treatment of male infertility. Practitioner, 211, 669.PubMedGoogle Scholar
  2. Berhrman, S. J. and Kistner, R. W. 1975.In “Progress in Infertility”. 2nd edition. Ed. by S. J. Behrman and R. W. Kistner. Boston. Little, Brown and Co. p. 1.Google Scholar
  3. Charny, C. W. 1956. Treatment of male infertility with large doses of testosterone. J. Amer. med. Assn. 160, 98.Google Scholar
  4. Comhaire, F. 1976. Treatment of oligospermia with tamoxifen. Int. J. Fert. 21, 232.Google Scholar
  5. Eliasson, R. 1971. Standards for investigation of human semen. Andrologie. 3 (2), suppl 49.Google Scholar
  6. Eliasson, R. and Lindholmer, C. 1972. Distribution and properties of spermatozoa in different fractions of split ejaculates. Fertil. Steril. 23, 252.PubMedGoogle Scholar
  7. Fairley, K. F., Barrie, J. U. and Johnson, W. 1972. Sterility and testicular atrophy related to cycophosphamide therapy. Lancet i, 568.CrossRefGoogle Scholar
  8. Getzoff, P. L. 1955. Clinical evaluation of testicular biopsy and the rebound phenomenon. Fertil. Steril. 6, 465.PubMedGoogle Scholar
  9. Giarola, A. and Ballerio, C. 1959. Modern therapies of seminal deficiency: arginine and other amino acids. Ann. Obst. Gynec. 81, 211.Google Scholar
  10. Haesungharern, A. and Chulavatnatol. 1973. Stimulation of human spermatozoal motility by caffeine. Fertil. Steril. 24, 662.Google Scholar
  11. Harrison, R. F., De Louvois, J., Blades, M. and Hurley, R. 1975. Doxycycline treatment in male infertility. Lancet i, 605.CrossRefGoogle Scholar
  12. Heller, C. G., Nelson, N. O. and Hill, I. B. 1950. Improvement in spermatogenesis following depression of the human testis with testosterone. Fertil. Steril. 1, 415.PubMedGoogle Scholar
  13. Heller, C. G., Wootton, P., Rowley, M. J., Lalli, M. F. and Brusca, D. R. 1965. Action of radiation upon spermatogenesis. Proceedings of the 6th Pan-American Congress of Endocrinology. International Congress Series No. 112. Amsterdam. Excerpta Medica. p. 408.Google Scholar
  14. Keller, D. W. and Polakoski, K. L. 1975. Arginine stimulation of human sperm motilityin vitro. Biol. Reprod. 13, 154.PubMedCrossRefGoogle Scholar
  15. Mellinger, R. C. and Thompson, R. J. 1966. The effect of clomiphene citrate in male infertility. Fertil. Steril. 17, 94.PubMedGoogle Scholar
  16. Mroueh, A., Lytton, B. and Kase, N. 1967. Effect of clomiphene citrate on oligospermia. Amer. J. Obstet. Gynec. 98, 1033.PubMedGoogle Scholar
  17. Perez-Pelaez, M. and Cohen, M. R. 1965. The split ejaculate in homologous insemination. Int. J. Fertil. 10, 25.PubMedGoogle Scholar
  18. Petry, R., Rausch-Strooman, J. G., Heinz, H. A., Senge, T. R. and Mauss, J. 1968. Androgen treatment without inhibiting effect on hypophysis and male gonads. Acta Endocrinologica (Kbh). 59, 497, 507.Google Scholar
  19. Richardson, D. W. 1976.In Proceedings of the 4th Study Group of the Royal College of Obstetricians and Gynaecologists. Ed. by M. Brudenell, A. McClaren, R. Short and M. Symonds. p. 116.Google Scholar
  20. Rock, J. and Robinson, D. 1965. Effect of induced intra scrotal hyperthermia on testicular function in man. Am. J. Obstet. Gynec. 93, 793.PubMedGoogle Scholar
  21. Rosemberg, E. 1976. Gonadotrophin therapy in male infertility.In “Human Semen and Fertility Regulation in Man”. Ed. by E. S. E. Hafez. St. Louis, C. V. Mosby, p. 464.Google Scholar
  22. Santen, R. J. and Paulsen, C. A. 1973. Hypogonadotrophic Eunuchoridism 1. Clinical study of the mode of inheritance. J. Clin. Endocrin. Metab. 36, 47.CrossRefGoogle Scholar
  23. Semm, K. 1966. A new instrument for artificial insemination. International Congress Series. Excerpta Medica. 6, 16.Google Scholar
  24. Schellen, T. C. M. 1970. Results with mesterolone in the treatment of disturbance of spermatogenesis. Andrologia. 2, 1.Google Scholar
  25. Schill, W. B. 1975. Improvement in sperm motility in patients with asthenospermia by Kallikrein treatment Int. J. Fertil. 20, 61.Google Scholar
  26. Schill, W. B. 1975. Kininogenaces 2. Kallikrein. Ed. by G. L. Haberland, J. W. Rohen, C. Schirren and P. Huber.Google Scholar
  27. Sheth, A. R., Johsi, L. R., Moodbidri, S. B. and Rao, S. S. 1973. Serum prolactin levels in fertile and infertile men. Andrologie. 5, 297.PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • W. Thompson
    • 1
  • A. I. Traub
    • 1
  1. 1.Department of Midwifery and GynaecologyThe Queen’s University of BelfastBelfastUK

Personalised recommendations