Epidemiology of hepatitis E virus in male blood donors in Jeddah, Saudi Arabia
To our knowledge, only a few epidemiological reports on the prevalence of hepatitis E antibodies in Saudi blood donors have been published.
Men of several nationalities, donating blood at King Khalid National Guard Hospital (Jeddah, Saudi Arabia) were selected (n = 593) for this study examining the seroprevalence of hepatitis E virus (HEV) in the local male donor population and testing the relationship of the antibody to HEV (anti-HEV) to donor characteristics using Odds Ratio (OR) and Chi-square statistic.
The prevalence of anti-HEV in the group examined was 16.9 per cent (100/593). The seroprevalence for Saudi donors was 14.8 per cent compared with 33.3 per cent for non-Saudis of Middle Eastern origin. Donors who were 40 yr and over had significantly higher seroprevalence than those donors who were 30 yr or younger (OR =2.5, p = 0.006). There was a significant association between anti-HEV and anti-HCV with donors who were positive to anti-HCV having about 5 times the risk of HEV than those who were anti-HCV negative (p = 0.02).
These findings demonstrate the high seroprevalence rate of anti-HEV among male blood donors in Saudi Arabia.
KeywordsBlood Donor Donor Characteristic Male Blood Donor Middle Eastern Origin High Seroprevalence Rate
- 3.Arif, M., Qattan, I., Al-Faleh, E. Ramia, S. Epidemiology of Hepatitis E virus (HEV) infection in Saudi Arabia. Annals of Trop. Med. and Parasitiology 1994; 88(2): 163–8.Google Scholar
- 4.Khuroo, M. S., Kamili, S., Yatto, G. N. Hepatitis E: current perspectives. Postgraduate Doctor (Middle East) 1995; 18(2): 58–65.Google Scholar
- 6.Keeffe, E. B., Benner, K. G. Hepatitis A through E: Distinguishing the etiologic agents. Modern Medicine (Middle East) 1993; 10: 48–62.Google Scholar
- 7.Zuckerman, A. J. Hepatitis E virus. The main cause of enterically transmitted non-A, non-B Hepatitis. Br. Med. J. 1990; 300: 1475–6.Google Scholar
- 12.Ritter, A., Flacke, H., Vornwald, A., Zaaijer, H., Saeed, A. A., Dawson, G., Simpson, B., Sutherland, R. A seroprevalence study of hepatitis E in Europe and the Middle East. Viral Hepatitis and Liver Disease 1994; 432–434.Google Scholar
- 13.Walker, R. H. (Ed.) Technical Manual of American Association of Blood Banks. American Association of Blood Banks. Bethesda MD. 1993. p 1–28.Google Scholar
- 21.Clayson, E. T., Myint, K. S. A., Snitbhan, R. et al. Viremia, fecal shedding, and IgM and IgG responses in patients with Hepatitis E. J Infect. Dis. 1995; 172: 927–33.Google Scholar