Irish Journal of Medical Science

, Volume 144, Supplement 1, pp 5–9 | Cite as

The clinical use of antibiotics

  • Hillas Smith
Antibiotics in Clinical Practice


In this short paper I have concentrated on a simpleclinical approach to the rational use of antibacterial agents. In stressing this bedside method, what I will call microbial thinking, I have excluded the difficulties of drug resistance, combined therapy, hypersensitivity and the constraints imposed by concomitant disease—particularly renal insufficiency. I have said nothing of the role of the microbiologist—essential for full understanding of problems in chemotherapy and whose collaboration is crucial. This restricted approach may have produced some distortion or even oversimplification of what is admittedly often an extremely complex situation, but I hope that the single-minded simplicity of the message may compensate for these deficiencies.


Blood Culture Typhoid Fever Sulphonamide IRISH Journal Bacillus Anthracis 
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Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • Hillas Smith
    • 1
  1. 1.The Royal Free HospitalLondon

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