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Immunomodulatory and therapeutic effect of lentinan in treating condyloma acuminatum

  • Yin Guangwen
  • Yu Jianbin
  • Li Dongqin
  • He Fucheng
  • Yin Huiqing
  • Fu Shizhen
Original Articles
  • 46 Downloads

Abstract

Objective: To observe the immunomodulatory and therapeutic effect of lentinan in treating condyloma acuminatum (CA).Methods: Thirty-six CA patients were randomly divided into two groups, 19 in the treated group treated with lentinan and CO2 laser irradiation, and 17 in the control group, treated with laser irradiation alone. Their T lymphocyte subsets of peripheral blood and level of serum interleukin-2 (IL-2) and soluble interleukin-2 receptor (SIL-2R) were determined before and after treatment, and the recurrence rates of the two groups were compared.Results: After treatment, in the treated group, the CD4/CD8 ratio, serum IL-2 raised and serum SIL-2R lowered significantly (P < 0.05, 0.05, 0.05 respectively) as compared with before treatment, while those parameters were not changed significantly in the control group. The recurrence rate of the treated group was lower than that of the control group.P < 0.05.Conclusion: Lentinan could modulate the cellular immunofunction of CA patients and reduce the recurrence rate of CA cases.

Key words

Lentinan condyloma acuminatum immunomodulation treatment 

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Copyright information

© The Chinese Journal of Integrated Traditional and Western Medicine Press 1999

Authors and Affiliations

  • Yin Guangwen
    • 1
  • Yu Jianbin
    • 1
  • Li Dongqin
    • 1
  • He Fucheng
    • 1
  • Yin Huiqing
    • 1
  • Fu Shizhen
    • 1
  1. 1.Department of DermatologyThe First Affiliated Hospital of Henan Medical UniversityZhengzhou

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