Medical Oncology and Tumor Pharmacotherapy

, Volume 3, Issue 3–4, pp 147–152 | Cite as

Immunotoxin therapy of malignant melanoma

  • Lynn E. Spitler


Current standard therapies for metastatic malignant melanoma are poor, and surgical excision of disease remains the cornerstone of melanoma management. Unmodified monoclonal antibodies have been used therapeutically in this, and other, malignancies, but results have been disappointing. This has led to attempts to improve the efficacy of monoclonal antibodies by using them to target therapeutic modalities to tumors. These therapeutic modalities include chemotherapeutic, radiotherapeutic and cytotoxic agents. An example of the latter is ricin A-chain, which is so potent that it has been reported that one molecule of it entering the cytosol is sufficient to cause cell death. Preclinical studies support the potential of immunotoxins as effective therapy for malignancy. A phase I–II trial of immunotoxin therapy of malignant melanoma has been completed and a trial to determine clinical efficacy has been implemented.

Key words

Immunotoxin Melanoma Monoclonal antibodies Immunotherapy 


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Copyright information

© Humana Press Inc. 1986

Authors and Affiliations

  • Lynn E. Spitler
    • 1
  1. 1.Department of Medicine, Children's HospitalSan Francisco and XOMA CorporationBerkeleyU.S.A.

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