Overnutrition facilitates the development of experimental tumors
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The summarising panel concluded that, inad lib.-fed and other rats with genetically-determined or carcinogen-induced tumors with numerous localisations, overnutrition does induce tumors or permit then to grow. Epidemiological studies suggest similar mechanisms in man, but with much fewer tumor localisations, and with much less certainty. The role played by saturated and unsaturated fat, the effect of fatty tissues on hormone metabolism, and the effect of soluble and insoluble dietary fiber can not yet be defined. Among areas for further study, epidemiology of genetic diseases becoming manifest during later life was mentioned, as was the need for improved dietary recall (‘bean-counting’) methods, the need to study interaction of nutrients, the need to study the metabolic effects of energy expenditure and physical exercise, and the need for risk assessment in the field of diet and cancer as compared to other fields. It was also agreed that observations disagreeing with the hypotheses advanced should be examined, for instance, the low cancer frequency both in beef-consuming Mormons and in vegetarian Seventh Day Adventists, or the high cancer frequency in Maoris consuming little fat.
KeywordsEndometrial Cancer Caloric Restriction Adipose Cell Decrease Body Weight Insoluble Dietary Fiber
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