Twelve cases of malignant hematopathy treated by combined therapy of hematopoietic stem cell transplantation and Chinese herbal medicine
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To evaluate the effect of hematopoietic stem cell transplantation combined with Chinese erbal medicine in treating malignant hematopathy.
Allo-bone marrow transplantation (allo-BMT) or allo-peripheral blood stem cell transplantation (allo-PBSCT), with conditioning regimen of60Co total body irradiation + Cyclophosphamide (TBI+ Cy) or busulfan + cyclophosphamide (Bu + Cy), was used to treat 4 cases of chronic granulocytic leukemia (CGL, 3 of chronic phase and 1 of accelerating phase) and one case of acute non-lymphocytic leukemia (ANLL). And auto-BMT or auto-PBSCT, with conditioning regimen of myleran + cytosino arabinoside + cyclophosphamide (MAC) or MAC+ VP16, was used to treat 7 cases of hematopathy, including 5 cases of ANLL (3 of CR1 and 2 of CR2) and 2 cases of malignant lymphoma (1 of the first occurrence and 1 of relapse). Chinese herbal medicine was given orally to all the 12 patients after transplantation according to TCM Syndrome Differentiation.
All patients were successfully engrafted. Within the median follow-up period of 18 (4-70) months, 1 patient (8.3%) died a transplantation-related death, 3 (25.0%) relapsed and 8 (66.7%) survived free of original disease.
Conclusion: Auto-BMT or auto-PBSCT in
CR1 stage of acute leukemia could reduce the relapse rate, when there was no matched bone marow donor; allo-BMT or allo-PBSCT in chronic stage could result in long-term disease-free survival of patients; Chinese herbal medicine administration in patients of malignant hematopathy after transplantation might reduce the complications and plays certain role in promoting recovery of hematopoietic function.
Key Wordsleukemia lymphoma hematopoietic stem cells transplantation Chinese herbal medicine
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