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Experimental study on effect of renal failure granule in treating uremia

  • Chen Wang
  • Ping-dong Zheng
  • Li-qun He
  • Yi Wang
Article
  • 17 Downloads

Abstract

Objective

To observe the efficacy of Renal Failure Granule (RFG) in treating uremia and explore its mechanism.

Methods

Piatt’s method was used to establish the chronic renal failure model. Forty-eight rats were divided into normal group, model group, Jiangzhuo recipe group, Fuzheng recipe group, RFG group and aldehyde-oxygen encapsulated starch group, 8 rats in each group, to observe the effects of RFG on serum creatinine (SCr), blood urea nitrogen (BUN), plasma calcium (Ca), plasma phosphorus (P), parathyroid hormone (PTH), middle molecular substance (MMS), methylguanidine (MG), guanidino-succinic acid (GSA) and other parameters.

Results

Comparison of SCr and BUN changes after medication for 30 and 60 days, the RFG group, the Fuzheng recipe group and the Jiangzhuo recipe group, with the aldehyde-oxygen encapsulated starch group or model group, demonstrated that the difference was significant (P<0.05,P<0.01), For PTH, Ca, P, MMS, MG and GSA, RFG was clearly different with the model group (P<0.05,P<0.01). Jiangzhuo recipe and Fuzheng recipe group also were variously efficacious in above-mentioned parameters.

Conclusions

RFG can retard the development of uremia, and its mechanism may be related to the decrease of uremic toxin.

Key words

uremia Renal Failure Granule toxin 

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References

  1. 1.
    Platt R, Roscoe MH, Smith FW. Experimental renal failure. Clin Sci 1952; 11: 217–231.PubMedGoogle Scholar
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    Zheng Pingdong. A study on the action of a modified wen-pi-tang prescription, using uremic toxins in blood as indices. Phytotherapy Research 1994; 3 (2): 26–27.Google Scholar
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    Ageta T, Sugino BZ. Renal insufficiency. Tokyo: Tokyo Medical Press, 1977: 88.Google Scholar
  4. 4.
    Xu PX. Current status of middle molecular substance. Bio-chem Commun 1988; (3): 28–30.Google Scholar

Copyright information

© The Chinese Journal of Integrated Traditional and Western Medicine Press 2002

Authors and Affiliations

  • Chen Wang
    • 1
  • Ping-dong Zheng
    • 1
  • Li-qun He
    • 1
  • Yi Wang
    • 1
  1. 1.Shuguang Hospital Affiliated to Shanghai University of TraditionalChinese MedicineShanghai

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