Study on abnormality and regulation of T-Lymphocyte subsets in peripheral blood of rheumatoid arthritis patients

Abstract

Objective

To investigate the change of T-lymphocyte subsets in peripheral blood of rheumatoid arthritis (RA) patients and analyze the effects of Fuzheng Qubi Decoction (FZQBD) on T-cell subsets.

Methods

Thirty RA patients were randomly divided into two groups, and treated with FZQBD or western medicine combination therapy respectively for one month, the percentage of peripheral CD₃ ⁺, CD₄ ⁺ , CD₈ ⁺ as well as the serum IgG and IgA levels were determined.

Results

The percentage of peripheral CD₄ ⁺ , CD₄ ⁺ /CD₈ ⁺ ratio, IgG and IgA levels increased significantly (p < 0.001) in RA patients before treatment. After 1 month of FZQBD treatment, the CD₄ ⁺ /CD₈ ⁺ ratio decreased obviously < 0.05).

Conclusion

Abnormal cellular immunity exists in RA patients, FZQBD could adjust the abnormal T-lymphocyte subsets to normalize it.