Study on abnormality and regulation of T-Lymphocyte subsets in peripheral blood of rheumatoid arthritis patients
To investigate the change of T-lymphocyte subsets in peripheral blood of rheumatoid arthritis (RA) patients and analyze the effects of Fuzheng Qubi Decoction (FZQBD) on T-cell subsets.
Thirty RA patients were randomly divided into two groups, and treated with FZQBD or western medicine combination therapy respectively for one month, the percentage of peripheral CD3+, CD4+ , CD8+ as well as the serum IgG and IgA levels were determined.
The percentage of peripheral CD4+ , CD4+ /CD8+ ratio, IgG and IgA levels increased significantly (p < 0.001) in RA patients before treatment. After 1 month of FZQBD treatment, the CD4+ /CD8+ ratio decreased obviously < 0.05).
Abnormal cellular immunity exists in RA patients, FZQBD could adjust the abnormal T-lymphocyte subsets to normalize it.